Cardiac replacement therapy: Critical issues and future perspectives of heart transplantation and artificial heart

Isabella Fumarulo, Andrea Stefanini, Daniele Masarone, Francesco Burzotta, Matteo Cameli, Nadia Aspromonte

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Diagnostic and therapeutic advances in the cardiovascular field have caused a progressive reduction in mortality from acute causes, with an ever-increasing chronicity of cardiovascular pathologies. In recent years, mechanical supports have played a fundamental role, allowing the patient to be stabilized in the most critical phase of acute heart failure (AHF) and acting as a "bridge" for definitive therapies. Heart transplantation (HTx) is the gold-standard treatment for end-stage HF, but it is burdened by a series of critical issues that limit its use, first of all the shortage of grafts. It also requires the patient to take immunosuppressive therapy for life, which exposes him to a greater risk of infectious and oncological diseases. For these reasons, in the last years, mechanical supports are increasingly used as "destination therapy", alternatively to HTx. However, also mechanical supports are not free from critical issues that limit their use. In this review we aim to analyze critical issues and future perspectives of advanced HF therapies.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaCurrent Problems in Cardiology
Volume50
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • Heart failure
  • Heart transplantation
  • Total artificial heart
  • Mechanical circulatory support
  • Left ventricular assist device

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