TY - JOUR
T1 - Cardiac replacement therapy: Critical issues and future perspectives of heart transplantation and artificial heart
AU - Fumarulo, Isabella
AU - Stefanini, Andrea
AU - Masarone, Daniele
AU - Burzotta, Francesco
AU - Cameli, Matteo
AU - Aspromonte, Nadia
PY - 2024
Y1 - 2024
N2 - Diagnostic and therapeutic advances in the cardiovascular field have caused a progressive reduction in mortality from acute causes, with an ever-increasing chronicity of cardiovascular pathologies. In recent years, mechanical supports have played a fundamental role, allowing the patient to be stabilized in the most critical phase of acute heart failure (AHF) and acting as a "bridge" for definitive therapies. Heart transplantation (HTx) is the gold-standard treatment for end-stage HF, but it is burdened by a series of critical issues that limit its use, first of all the shortage of grafts. It also requires the patient to take immunosuppressive therapy for life, which exposes him to a greater risk of infectious and oncological diseases. For these reasons, in the last years, mechanical supports are increasingly used as "destination therapy", alternatively to HTx. However, also mechanical supports are not free from critical issues that limit their use. In this review we aim to analyze critical issues and future perspectives of advanced HF therapies.
AB - Diagnostic and therapeutic advances in the cardiovascular field have caused a progressive reduction in mortality from acute causes, with an ever-increasing chronicity of cardiovascular pathologies. In recent years, mechanical supports have played a fundamental role, allowing the patient to be stabilized in the most critical phase of acute heart failure (AHF) and acting as a "bridge" for definitive therapies. Heart transplantation (HTx) is the gold-standard treatment for end-stage HF, but it is burdened by a series of critical issues that limit its use, first of all the shortage of grafts. It also requires the patient to take immunosuppressive therapy for life, which exposes him to a greater risk of infectious and oncological diseases. For these reasons, in the last years, mechanical supports are increasingly used as "destination therapy", alternatively to HTx. However, also mechanical supports are not free from critical issues that limit their use. In this review we aim to analyze critical issues and future perspectives of advanced HF therapies.
KW - Heart failure
KW - Heart transplantation
KW - Total artificial heart
KW - Mechanical circulatory support
KW - Left ventricular assist device
KW - Heart failure
KW - Heart transplantation
KW - Total artificial heart
KW - Mechanical circulatory support
KW - Left ventricular assist device
UR - http://hdl.handle.net/10807/303844
U2 - 10.1016/j.cpcardiol.2024.102971
DO - 10.1016/j.cpcardiol.2024.102971
M3 - Article
SN - 0146-2806
VL - 50
SP - N/A-N/A
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
ER -