TY - JOUR
T1 - Cardiac magnetic resonance in systemic sclerosis patients with cardiac symptoms.
AU - Meduri, Agostino
AU - Natale, Luigi
AU - Manfredi, Riccardo
AU - Di Molfetta, Domenico Vito
AU - Di Molfetta, D. V.
PY - 2017
Y1 - 2017
N2 - OBJECTIVE: Systemic sclerosis
(SSc) is characterized by widespread vascular
lesions and skin and internal organs fibrosis, including
the heart; all cardiac layers, endocardium,
myocardium, and pericardium, may be involved.
We report the relevance of cardiac MRI
findings in scleroderma patients with cardiac
symptoms.
PATIENTS AND METHODS: 50 patients, all fulfilling
the ACR SSc criteria (19 with limited and
31 with diffused skin involvement) were evaluated
using a 1.5T MR scanner. Images were acquired
before and after contrast medium administration;
the exams were considered positive
with one or more of these findings: enlarged volumes,
reduced EF, regional kinetic anomalies,
edema, DE or pericardial effusion.
RESULTS: 40 patients (80%) had one or more
cardiac abnormalities: 5 patients had myocardial
edema; 2 an increased interventricular septum
thickness; 22 dilated ventricles or reduced
EF; 12 an abnormal regional ventricular motion
(2 of these with akinetic segments); 17 a delayed
enhancement with different patterns, all without
coronary distribution; 22 a pericardial effusion
CONCLUSIONS: Pathologic findings were documented
in 80% of the cases confirming a high
occurrence of abnormal MR data. Myocardial involvement
in systemic sclerosis can be assumed
by the presence of multiple pathologic MRI findings.
CMR seems to be a valuable tool to identify
and assess the presence of cardiac involvement.
AB - OBJECTIVE: Systemic sclerosis
(SSc) is characterized by widespread vascular
lesions and skin and internal organs fibrosis, including
the heart; all cardiac layers, endocardium,
myocardium, and pericardium, may be involved.
We report the relevance of cardiac MRI
findings in scleroderma patients with cardiac
symptoms.
PATIENTS AND METHODS: 50 patients, all fulfilling
the ACR SSc criteria (19 with limited and
31 with diffused skin involvement) were evaluated
using a 1.5T MR scanner. Images were acquired
before and after contrast medium administration;
the exams were considered positive
with one or more of these findings: enlarged volumes,
reduced EF, regional kinetic anomalies,
edema, DE or pericardial effusion.
RESULTS: 40 patients (80%) had one or more
cardiac abnormalities: 5 patients had myocardial
edema; 2 an increased interventricular septum
thickness; 22 dilated ventricles or reduced
EF; 12 an abnormal regional ventricular motion
(2 of these with akinetic segments); 17 a delayed
enhancement with different patterns, all without
coronary distribution; 22 a pericardial effusion
CONCLUSIONS: Pathologic findings were documented
in 80% of the cases confirming a high
occurrence of abnormal MR data. Myocardial involvement
in systemic sclerosis can be assumed
by the presence of multiple pathologic MRI findings.
CMR seems to be a valuable tool to identify
and assess the presence of cardiac involvement.
KW - Cardiac magnetic resonance
KW - Delayed enhancement
KW - Systemic sclerosis
KW - Cardiac magnetic resonance
KW - Delayed enhancement
KW - Systemic sclerosis
UR - http://hdl.handle.net/10807/122835
M3 - Article
SP - 4797
EP - 4803
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
ER -