Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy

DE Yung*, E Rondonotti, A Giannakou, T Avni, B Rosa, E Toth, AJ Lucendo, R Sidhu, H Beaumont, P Ellul, L Negreanu, VA Jimenez-Garcia, D McNamara, U Kopylov, L Elli, K Triantafyllou, F Shibli, Maria Elena Riccioni, M Bruno, X DrayJN Plevris, A Koulaouzidis, F Arguelles-Arias, A Becq, F Branchi, MA Tejero-Bustos, J Cotter, R Eliakim, F Ferretti, IM Gralnek, JM Herrerias-Gutierrez, M Hussey, M Jacobs, GW Johansson, M McAlindon, S Montiero, A Nemeth, M Pennazio, D Rattehalli, A Stemate, A Tortora, G Tziatzios

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

13 Citazioni (Scopus)

Abstract

Background: Recent data imply young patients (age <= 50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology.Materials and methods: This was a retrospective, multicentre study (2010-2015) in consecutive, young patients (<= 50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression.Results: Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 +/- 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn's disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3-11.3; p=0.01; and OR: 0.96; 95%CI: 0.92-0.99; p=0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn.Conclusion: In IDA patients <= 50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.
Lingua originaleInglese
pagine (da-a)974-981
Numero di pagine8
RivistaUnited European Gastroenterology Journal
Volume5
Numero di pubblicazione7
DOI
Stato di pubblicazionePubblicato - 2017

All Science Journal Classification (ASJC) codes

  • Oncologia
  • Gastroenterologia

Keywords

  • Capsule endoscopy
  • iron deficiency anaemia
  • neoplasia
  • small bowel
  • young

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