Capillary electrophoresis-mass spectrometry: recent trends in clinical proteomics.

Federica Iavarone, Claudia Desiderio, Diana Valeria Rossetti, Irene Messana, Massimo Castagnola

Risultato della ricerca: Contributo in rivistaArticolo in rivista

39 Citazioni (Scopus)

Abstract

The increasing attention now paid to the elucidation of human proteome strengthened the development of analytical instruments able to provide reliable proteins and peptides quantitation and characterization in biological fluids and tissues. Emerging from proteomics, clinical proteomics exclusively considers as biomedical applications. It evaluates, often by high-throughput comparative platforms. the protein and peptide variations in body fluids, cells and tissues under different physiological and pathological conditions with the aim of discovering disease biomarkers. Among the available analytical methodologies, mass spectrometry in coupling with liquid chromatography or capillary electrophoresis demonstrated to be the eligible technique for protein detection and identification This review summarizes the most recent applications of capillary electrophoresis-mass spectrometry to clinical proteomics, focusing on capillary zone electrophoresis separation mode and ESI and MALDI ionizations, which are the most frequently applied capillary electrophoresis-mass spectrometry hyphenated techniques, (C) 2010 Elsevier B V. All rights reserved.
Lingua originaleEnglish
pagine (da-a)1161-1169
Numero di pagine9
RivistaJournal of Pharmaceutical and Biomedical Analysis
Volume2010
Stato di pubblicazionePubblicato - 2010

Keywords

  • capillary
  • proteomics

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