Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)

Luisa Vicari, Cristina Colarossi, Dario Giuffrida, Ruggero De Maria Marchiano, Lorenzo Memeo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

15 Citazioni (Scopus)


A number of studies have indicated that tumor growth and proliferation is dependent on a small subset of cells, defined as cancer stem cells (CSCs). CSCs have the capability to self-renew, and are involved with cancer propagation, relapse and metastatic dissemination. CSCs have been isolated from numerous tissues, including normal and cancerous thyroid tissue. A regulatory network of signaling pathways and microRNAs (miRNAs) control the properties of CSCs. Differentiated thyroid carcinoma is the most common type of endocrine cancer, with an increasing incidence. Anaplastic thyroid carcinoma is the most rare type of endocrine cancer; however, it also exhibits the highest mortality rate among thyroid malignancies, with an extremely short survival time. Thyroid CSCs are invasive and highly resistant to conventional therapies, including radiotherapy and chemotherapy, which results in disease relapse even when the primary lesion has been eradicated. Therefore, targeting thyroid CSCs may represent an effective treatment strategy against aggressive neoplasms, including recurrent and radioresistant tumors. The present review summarizes the current literature regarding thyroid CSCs and discusses therapeutic strategies that target these cells, with a focus on the function of self-renewal pathways and miRNAs. Elucidation of the mechanisms that regulate CSC growth and survival may improve novel therapeutic approaches for treatment-resistant thyroid cancers.
Lingua originaleEnglish
pagine (da-a)2254-2260
Numero di pagine7
RivistaOncology Letters
Stato di pubblicazionePubblicato - 2016


  • Cancer Research
  • Effective strategies
  • Oncology
  • Thyroid cancer stem cells


Entra nei temi di ricerca di 'Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review)'. Insieme formano una fingerprint unica.

Cita questo