Cancer stem cells: are they responsible for treatment failure?

Ruggero De Maria Marchiano, Marcello Maugeri-Saccà, Patrizia Vici, Luigi Di Lauro, Maddalena Barba, Carla Azzurra Amoreo, Enzo Gallo, Marcella Mottolese

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Overcoming resistance to standard anticancer treatments represents a signi cant challenge. The interest regarding cancer stem cells, a cellular population that has the ability to self-renew and to propagate the tumor, was prompted by experimental evidence delineating the molecular mechanisms that are selectively activated in this cellular subset in order to survive chemotherapy. This has also stimulated combination strategies aimed at rendering cancer stem cells vulnerable to anticancer agents. Moreover, cancer stem cells o er a unique opportunity for modeling human cancers in mice, thus emerging as a powerful tool for testing novel drugs and combinations in a simulation of human disease. These novel animal models may lay the foundation for a new generation of clinical trials aimed at anticipating the bene t to patients of anticancer therapies.
Lingua originaleEnglish
pagine (da-a)2033-2044
Numero di pagine12
RivistaFuture Oncology
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • apoptotic pathways • cancer stem cells • chemotherapy • clonal evolution • CSC-derived xenografts • di erentiation • DNA damage repair • hierarchical model • self-renewal pathways • survival pathways

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