Cancer stem cell definitions and terminology: the devil is in the details

Peter Valent; Dominique Bonnet; Ruggero De Maria Marchiano; Tsvee Lapidot; Mhairi Copland; Junia V. Melo; Christine Chomienne; Fumihiko Ishikawa; Jan Jacob Schuringa; Giorgio Stassi; Brian Huntly; Harald Herrmann; Jean Soulier; Alexander Roesch; Gerrit Jan Schuurhuis; Stefan Wöhrer; Michel Arock; Johannes Zuber; Sabine Cerny-Reiterer; Hans E. Johnsen; Michael Andreeff; Connie Eaves

doi:10.1038/nrc3368

Cancer stem cell definitions and terminology: the devil is in the details

Peter Valent, Dominique Bonnet, Ruggero De Maria Marchiano, Tsvee Lapidot, Mhairi Copland, Junia V. Melo, Christine Chomienne, Fumihiko Ishikawa, Jan Jacob Schuringa, Giorgio Stassi, Brian Huntly, Harald Herrmann, Jean Soulier, Alexander Roesch, Gerrit Jan Schuurhuis, Stefan Wöhrer, Michel Arock, Johannes Zuber, Sabine Cerny-Reiterer, Hans E. JohnsenMichael Andreeff, Connie Eaves

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

441 Citazioni (SciVal)

Abstract

The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.

Lingua originale	English
pagine (da-a)	767-775
Numero di pagine	9
Rivista	Nature Reviews Cancer
DOI	https://doi.org/10.1038/nrc3368
Stato di pubblicazione	Pubblicato - 2012

Keywords

Cancer stem cells (CSC)

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Valent, P., Bonnet, D., De Maria Marchiano, R., Lapidot, T., Copland, M., Melo, J. V., Chomienne, C., Ishikawa, F., Schuringa, J. J., Stassi, G., Huntly, B., Herrmann, H., Soulier, J., Roesch, A., Schuurhuis, G. J., Wöhrer, S., Arock, M., Zuber, J., Cerny-Reiterer, S., ... Eaves, C. (2012). Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews Cancer, 767-775. https://doi.org/10.1038/nrc3368

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title = "Cancer stem cell definitions and terminology: the devil is in the details",

abstract = "The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.",

keywords = "Cancer stem cells (CSC), Cancer stem cells (CSC)",

author = "Peter Valent and Dominique Bonnet and {De Maria Marchiano}, Ruggero and Tsvee Lapidot and Mhairi Copland and Melo, {Junia V.} and Christine Chomienne and Fumihiko Ishikawa and Schuringa, {Jan Jacob} and Giorgio Stassi and Brian Huntly and Harald Herrmann and Jean Soulier and Alexander Roesch and Schuurhuis, {Gerrit Jan} and Stefan W{\"o}hrer and Michel Arock and Johannes Zuber and Sabine Cerny-Reiterer and Johnsen, {Hans E.} and Michael Andreeff and Connie Eaves",

year = "2012",

doi = "10.1038/nrc3368",

language = "English",

pages = "767--775",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

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Valent, P, Bonnet, D, De Maria Marchiano, R, Lapidot, T, Copland, M, Melo, JV, Chomienne, C, Ishikawa, F, Schuringa, JJ, Stassi, G, Huntly, B, Herrmann, H, Soulier, J, Roesch, A, Schuurhuis, GJ, Wöhrer, S, Arock, M, Zuber, J, Cerny-Reiterer, S, Johnsen, HE, Andreeff, M & Eaves, C 2012, 'Cancer stem cell definitions and terminology: the devil is in the details', Nature Reviews Cancer, pagg. 767-775. https://doi.org/10.1038/nrc3368

TY - JOUR

T1 - Cancer stem cell definitions and terminology: the devil is in the details

AU - Valent, Peter

AU - Bonnet, Dominique

AU - De Maria Marchiano, Ruggero

AU - Lapidot, Tsvee

AU - Copland, Mhairi

AU - Melo, Junia V.

AU - Chomienne, Christine

AU - Ishikawa, Fumihiko

AU - Schuringa, Jan Jacob

AU - Stassi, Giorgio

AU - Huntly, Brian

AU - Herrmann, Harald

AU - Soulier, Jean

AU - Roesch, Alexander

AU - Schuurhuis, Gerrit Jan

AU - Wöhrer, Stefan

AU - Arock, Michel

AU - Zuber, Johannes

AU - Cerny-Reiterer, Sabine

AU - Johnsen, Hans E.

AU - Andreeff, Michael

AU - Eaves, Connie

PY - 2012

Y1 - 2012

N2 - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.

AB - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.

KW - Cancer stem cells (CSC)

UR - http://hdl.handle.net/10807/111518

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DO - 10.1038/nrc3368

M3 - Article

SN - 1474-175X

SP - 767

EP - 775

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

ER -

Cancer stem cell definitions and terminology: the devil is in the details

Abstract

Keywords

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