Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

G. Ceglie; Baldo G. Del; E. Agolini; M. Rinelli; A. Cacchione; Bufalo F. Del; M. Vinci; R. Carta; L. Boccuto; E. Miele; Angela Mastronuzzi; Franco Locatelli; A. Carai

doi:10.3389/fped.2020.561487

Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

G. Ceglie
, Baldo G. Del
, E. Agolini
, M. Rinelli
, A. Cacchione
, Bufalo F. Del
, M. Vinci
, R. Carta
, L. Boccuto
, E. Miele
, Angela Mastronuzzi^*
, Franco Locatelli
, A. Carai

^*Autore corrispondente per questo lavoro

IRCCS Ospedale pediatrico Bambino Gesù - Roma
Clemson University
Greenwood Genetics Center

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

Lingua originale	Inglese
pagine (da-a)	1-10
Numero di pagine	10
Rivista	Frontiers in Pediatrics
Volume	8
Numero di pubblicazione	8
DOI	https://doi.org/10.3389/fped.2020.561487
Stato di pubblicazione	Pubblicato - 2020

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Pediatria, Perinatologia e Salute del Bambino

Keywords

brain tumors
cancer predisposition
genetics of cancer
high grade gliomas
pediatric neuro- oncology

Accesso al documento

10.3389/fped.2020.561487

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abstract = "Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.",

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AU - Ceglie, G.

AU - Del, Baldo G.

AU - Agolini, E.

AU - Rinelli, M.

AU - Cacchione, A.

AU - Del, Bufalo F.

AU - Vinci, M.

AU - Carta, R.

AU - Boccuto, L.

AU - Miele, E.

AU - Mastronuzzi, Angela

AU - Locatelli, Franco

AU - Carai, A.

PY - 2020

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AB - Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

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KW - cancer predisposition

KW - genetics of cancer

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Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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