Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Giulia Ceglie; Giada Del Baldo; Emanuele Agolini; Martina Rinelli; Antonella Cacchione; Francesca Del Bufalo; Maria Vinci; Roberto Carta; Luigi Boccuto; Evelina Miele; Angela Mastronuzzi; Franco Locatelli; Andrea Carai

doi:10.3389/fped.2020.561487

Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Giulia Ceglie, Giada Del Baldo, Emanuele Agolini, Martina Rinelli, Antonella Cacchione, Francesca Del Bufalo, Maria Vinci, Roberto Carta, Luigi Boccuto, Evelina Miele, Angela Mastronuzzi, Franco Locatelli, Andrea Carai

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

Lingua originale	English
pagine (da-a)	1-10
Numero di pagine	10
Rivista	Frontiers in Pediatrics
Volume	8
DOI	https://doi.org/10.3389/fped.2020.561487
Stato di pubblicazione	Pubblicato - 2020

Keywords

brain tumors
cancer predisposition
pediatric neuro- oncology
high grade gliomas
genetics of cancer

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title = "Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas",

abstract = "Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.",

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author = "Giulia Ceglie and {Del Baldo}, Giada and Emanuele Agolini and Martina Rinelli and Antonella Cacchione and {Del Bufalo}, Francesca and Maria Vinci and Roberto Carta and Luigi Boccuto and Evelina Miele and Angela Mastronuzzi and Franco Locatelli and Andrea Carai",

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doi = "10.3389/fped.2020.561487",

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T1 - Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

AU - Ceglie, Giulia

AU - Del Baldo, Giada

AU - Agolini, Emanuele

AU - Rinelli, Martina

AU - Cacchione, Antonella

AU - Del Bufalo, Francesca

AU - Vinci, Maria

AU - Carta, Roberto

AU - Boccuto, Luigi

AU - Miele, Evelina

AU - Mastronuzzi, Angela

AU - Locatelli, Franco

AU - Carai, Andrea

PY - 2020

Y1 - 2020

N2 - Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

AB - Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.

KW - brain tumors

KW - cancer predisposition

KW - pediatric neuro- oncology

KW - high grade gliomas

KW - genetics of cancer

KW - brain tumors

KW - cancer predisposition

KW - pediatric neuro- oncology

KW - high grade gliomas

KW - genetics of cancer

UR - http://hdl.handle.net/10807/229463

U2 - 10.3389/fped.2020.561487

DO - 10.3389/fped.2020.561487

M3 - Article

SN - 2296-2360

VL - 8

SP - 1

EP - 10

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

ER -

Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Abstract

Keywords

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