TY - JOUR
T1 - Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
AU - Carta, R.
AU - Del, Baldo G.
AU - Miele, E.
AU - Po, A.
AU - Besharat, Z. M.
AU - Nazio, F.
AU - Colafati, G. S.
AU - Piccirilli, E.
AU - Agolini, E.
AU - Rinelli, M.
AU - Lodi, M.
AU - Cacchione, A.
AU - Carai, A.
AU - Boccuto, L.
AU - Ferretti, E.
AU - Locatelli, Franco
AU - Mastronuzzi, A.
PY - 2020
Y1 - 2020
N2 - Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
AB - Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
KW - cancer genes
KW - cancer predisposition
KW - cancer syndromes
KW - hereditary neoplastic syndromes
KW - medulloblastoma
KW - pediatric brain tumors
KW - cancer genes
KW - cancer predisposition
KW - cancer syndromes
KW - hereditary neoplastic syndromes
KW - medulloblastoma
KW - pediatric brain tumors
UR - https://publicatt.unicatt.it/handle/10807/229136
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85095984558&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095984558&origin=inward
U2 - 10.3389/fonc.2020.566822
DO - 10.3389/fonc.2020.566822
M3 - Article
SN - 2234-943X
VL - 10
SP - 1
EP - 16
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - 10
ER -
