Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

S Falso; Marco Gessi; S Marini; R Benvenuto; E Sabatelli; A D'Amati; M Marini; A Evoli; Raffaele Iorio

doi:10.1002/ana.27033

Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

S Falso
, Marco Gessi
, S Marini
, R Benvenuto
, E Sabatelli
, A D'Amati
, M Marini
, A Evoli
, Raffaele Iorio^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset.

Lingua originale	Inglese
pagine (da-a)	1020-1025
Numero di pagine	6
Rivista	Annals of Neurology
Volume	96
Numero di pubblicazione	5
DOI	https://doi.org/10.1002/ana.27033
Stato di pubblicazione	Pubblicato - 2024

All Science Journal Classification (ASJC) codes

Neurologia
Neurologia (clinica)

Keywords

n/a

OSS delle Nazioni Unite

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10.1002/ana.27033

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abstract = "Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8\%). Patients with cancer were significantly older at time of MuSK-MG onset.",

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doi = "10.1002/ana.27033",

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T1 - Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

AU - Falso, S

AU - Gessi, Marco

AU - Marini, S

AU - Benvenuto, R

AU - Sabatelli, E

AU - D'Amati, A

AU - Marini, M

AU - Evoli, A

AU - Iorio, Raffaele

PY - 2024

Y1 - 2024

N2 - Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset.

AB - Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset.

KW - n/a

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M3 - Article

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JF - Annals of Neurology

IS - 5

ER -

Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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