Can environment or allergy explain international variation in prevalence of wheeze in childhood?

G. Weinmayr; A. Jaensch; Ruelius A. -K.; F. Forastiere; D. P. Strachan; S. K. Weiland; G. Buchele; C. Dentler; A. Jaensch; P. Rzehak; G. Weinmayr; A. Priftanji; A. Shkurti; J. Simenati; E. Grabocka; K. Shyti; S. Agolli; A. Gurakuqi; R. T. Stein; M. U. de Pereira; M. H. Jones; P. M. Pitrez; P. J. Cooper; M. Chico; Y. Z. Chen; N. S. Zhong; C. K. W. Lai; G. W. K. Wong; Riikjarv M. -A.; T. Annus; I. Annesi-Maesano; M. Gotua; M. Rukhadze; T. Abramidze; I. Kvachadze; L. Karsanidze; M. Kiladze; N. Dolidze; W. Leupold; U. Keil; E. von Mutius; S. K. Weiland; E. von Mutius; U. Keil; S. K. Weiland; P. Arthur; E. Addo-Yobo; C. Gratziou; K. Priftis; A. Papadopoulou; C. Katsardis; J. Tsanakas; E. Hatziagorou; F. Kirvassilis; M. Clausen; J. R. Shah; R. S. Mathur; R. P. Khubchandani; S. Mantri; F. Forastiere; Domenicantonio R. Di; Sario M. De; S. Sammarro; R. Pistelli; M. G. Serra; G. Corbo; C. A. Perucci; V. Svabe; D. Sebre; G. Casno; I. Novikova; L. Bagrade; B. Brunekreef; D. Schram; G. Doekes; Vliet P. H. N. Jansen-van; N. A. H. Janssen; F. J. H. Aarts; G. de Meer; J. Crane; K. Wickens; D. Barry; W. Nystad; R. Bolle; E. Lund; Garrido J. Batlles; Ruiz T. Rubi; Perales A. Bonillo; Jimenez Y. Gonzalez; Rodriguez J. Aguirre; deCabo J. Momblan; Maldonado A. Losilla; Torres M. Daza; L. Garcia-Marcos; Torres A. Martinez; Perez J. J. Guillen; Lopez A. Pinana; Robles S. Castejon; Hernandez G. Garcia; Gimeno A. Martinez; Rodriguez A. L. Moro; Paredes C. Luna; Gil I. Gonzalez; Suarez-Varela M. M. Morales; Gonzalez A. Llopis; Montaner A. Escribano; Guerola M. Tallon; L. Braback; M. Kjellman; L. Nilsson; Mai X. -M.; L. Braback; A. Sandin; Y. Saraclar; S. Kuyucu; A. Tuncer; C. Sackesen; V. Sumbuloglu; P. Geyik; C. Kocabas; D. P. Strachan; B. Kaur; N. El-Sharif; B. Nemery; F. Barghuthy; Huij S. Abu; M. Qlebo; M. van Hage; N. Ait-Khaled; H. R. Anderson; D. P. Strachan; C. Flohr; H. Williams; F. Forastiere; I. Asher; P. Ellwood; A. Stewart; E. Mitchell; J. Crane; N. Pearce; R. Beasley; B. Bjorksten; B. Brunekreef; S. Foliaki; L. Garcia-Marcos; E. von Mutius; U. Keil; S. K. Weiland; G. Weinmayr; C. K. W. Lai; J. Mallol; S. Montefort; J. Odhiambo; C. Robertson

doi:10.1007/s10654-018-0463-z

Can environment or allergy explain international variation in prevalence of wheeze in childhood?

G. Weinmayr^*, A. Jaensch, Ruelius A. -K., F. Forastiere, D. P. Strachan, S. K. Weiland, G. Buchele, C. Dentler, A. Jaensch, P. Rzehak, G. Weinmayr^*, A. Priftanji, A. Shkurti, J. Simenati, E. Grabocka, K. Shyti, S. Agolli, A. Gurakuqi, R. T. Stein, M. U. de PereiraM. H. Jones, P. M. Pitrez, P. J. Cooper, M. Chico, Y. Z. Chen, N. S. Zhong, C. K. W. Lai, G. W. K. Wong, Riikjarv M. -A., T. Annus, I. Annesi-Maesano, M. Gotua, M. Rukhadze, T. Abramidze, I. Kvachadze, L. Karsanidze, M. Kiladze, N. Dolidze, W. Leupold, U. Keil, E. von Mutius, S. K. Weiland, E. von Mutius, U. Keil, S. K. Weiland, P. Arthur, E. Addo-Yobo, C. Gratziou, K. Priftis, A. Papadopoulou, C. Katsardis, J. Tsanakas, E. Hatziagorou, F. Kirvassilis, M. Clausen, J. R. Shah, R. S. Mathur, R. P. Khubchandani, S. Mantri, F. Forastiere, Domenicantonio R. Di, Sario M. De, S. Sammarro, R. Pistelli, M. G. Serra, G. Corbo, C. A. Perucci, V. Svabe, D. Sebre, G. Casno, I. Novikova, L. Bagrade, B. Brunekreef, D. Schram, G. Doekes, Vliet P. H. N. Jansen-van, N. A. H. Janssen, F. J. H. Aarts, G. de Meer, J. Crane, K. Wickens, D. Barry, W. Nystad, R. Bolle, E. Lund, Garrido J. Batlles, Ruiz T. Rubi, Perales A. Bonillo, Jimenez Y. Gonzalez, Rodriguez J. Aguirre, deCabo J. Momblan, Maldonado A. Losilla, Torres M. Daza, L. Garcia-Marcos, Torres A. Martinez, Perez J. J. Guillen, Lopez A. Pinana, Robles S. Castejon, Hernandez G. Garcia, Gimeno A. Martinez, Rodriguez A. L. Moro, Paredes C. Luna, Gil I. Gonzalez, Suarez-Varela M. M. Morales, Gonzalez A. Llopis, Montaner A. Escribano, Guerola M. Tallon, L. Braback, M. Kjellman, L. Nilsson, Mai X. -M., L. Braback, A. Sandin, Y. Saraclar, S. Kuyucu, A. Tuncer, C. Sackesen, V. Sumbuloglu, P. Geyik, C. Kocabas, D. P. Strachan, B. Kaur, N. El-Sharif, B. Nemery, F. Barghuthy, Huij S. Abu, M. Qlebo, M. van Hage, N. Ait-Khaled, H. R. Anderson, D. P. Strachan, C. Flohr, H. Williams, F. Forastiere, I. Asher, P. Ellwood, A. Stewart, E. Mitchell, J. Crane, N. Pearce, R. Beasley, B. Bjorksten, B. Brunekreef, S. Foliaki, L. Garcia-Marcos, E. von Mutius, U. Keil, S. K. Weiland, G. Weinmayr^*, C. K. W. Lai, J. Mallol, S. Montefort, J. Odhiambo, C. Robertson

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

2 Citazioni (Scopus)

Abstract

Asthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8–12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in prevalence of recent wheeze. Adjustment for single individual-level risk factors changed the centre-level variation from a reduction of up to 8.4% (and 8.5% for atopy) to an increase of up to 6.8%. Modelling the 11 most influential environmental factors among all children simultaneously, the centre-level variation changed little overall (2.4% increase). Modelling only factors that decreased the variance, the 6 most influential factors (synthetic and feather quilt, mother’s smoking, heating stoves, dampness and foam pillows) in combination resulted in a 21% reduction in variance. Ecological (centre-level) risk factors generally explained higher proportions of the variation than did individual risk factors. Single environmental factors and aeroallergen sensitisation measured at the individual (child) level did not explain much of the between-centre variation in wheeze prevalence.

Lingua originale	Inglese
pagine (da-a)	509-520
Numero di pagine	12
Rivista	European Journal of Epidemiology
Volume	34
Numero di pubblicazione	5
DOI	https://doi.org/10.1007/s10654-018-0463-z
Stato di pubblicazione	Pubblicato - 2019
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Epidemiologia

Keywords

Asthma
Child
Environment
Environmental risk factors
Global Health
Humans
Hypersensitivity
International variation
Prevalence
Risk Factors
Surveys and Questionnaires

Accesso al documento

10.1007/s10654-018-0463-z

Altri file e collegamenti

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Weinmayr, G., Jaensch, A., -K., R. A., Forastiere, F., Strachan, D. P., Weiland, S. K., Buchele, G., Dentler, C., Jaensch, A., Rzehak, P., Weinmayr, G., Priftanji, A., Shkurti, A., Simenati, J., Grabocka, E., Shyti, K., Agolli, S., Gurakuqi, A., Stein, R. T., ... Robertson, C. (2019). Can environment or allergy explain international variation in prevalence of wheeze in childhood? European Journal of Epidemiology, 34(5), 509-520. https://doi.org/10.1007/s10654-018-0463-z

@article{5831f83702914b8b87a9c650c9cd4ccc,

title = "Can environment or allergy explain international variation in prevalence of wheeze in childhood?",

abstract = "Asthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8–12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in prevalence of recent wheeze. Adjustment for single individual-level risk factors changed the centre-level variation from a reduction of up to 8.4% (and 8.5% for atopy) to an increase of up to 6.8%. Modelling the 11 most influential environmental factors among all children simultaneously, the centre-level variation changed little overall (2.4% increase). Modelling only factors that decreased the variance, the 6 most influential factors (synthetic and feather quilt, mother{\textquoteright}s smoking, heating stoves, dampness and foam pillows) in combination resulted in a 21% reduction in variance. Ecological (centre-level) risk factors generally explained higher proportions of the variation than did individual risk factors. Single environmental factors and aeroallergen sensitisation measured at the individual (child) level did not explain much of the between-centre variation in wheeze prevalence.",

keywords = "Asthma, Child, Environment, Environmental risk factors, Global Health, Humans, Hypersensitivity, International variation, Prevalence, Risk Factors, Surveys and Questionnaires, Asthma, Child, Environment, Environmental risk factors, Global Health, Humans, Hypersensitivity, International variation, Prevalence, Risk Factors, Surveys and Questionnaires",

author = "G. Weinmayr and A. Jaensch and -K., {Ruelius A.} and F. Forastiere and Strachan, {D. P.} and Weiland, {S. K.} and G. Buchele and C. Dentler and A. Jaensch and P. Rzehak and G. Weinmayr and A. Priftanji and A. Shkurti and J. Simenati and E. Grabocka and K. Shyti and S. Agolli and A. Gurakuqi and Stein, {R. T.} and {de Pereira}, {M. U.} and Jones, {M. H.} and Pitrez, {P. M.} and Cooper, {P. J.} and M. Chico and Chen, {Y. Z.} and Zhong, {N. S.} and Lai, {C. K. W.} and Wong, {G. W. K.} and -A., {Riikjarv M.} and T. Annus and I. Annesi-Maesano and M. Gotua and M. Rukhadze and T. Abramidze and I. Kvachadze and L. Karsanidze and M. Kiladze and N. Dolidze and W. Leupold and U. Keil and {von Mutius}, E. and Weiland, {S. K.} and {von Mutius}, E. and U. Keil and Weiland, {S. K.} and P. Arthur and E. Addo-Yobo and C. Gratziou and K. Priftis and A. Papadopoulou and C. Katsardis and J. Tsanakas and E. Hatziagorou and F. Kirvassilis and M. Clausen and Shah, {J. R.} and Mathur, {R. S.} and Khubchandani, {R. P.} and S. Mantri and F. Forastiere and Di, {Domenicantonio R.} and De, {Sario M.} and S. Sammarro and R. Pistelli and Serra, {M. G.} and G. Corbo and Perucci, {C. A.} and V. Svabe and D. Sebre and G. Casno and I. Novikova and L. Bagrade and B. Brunekreef and D. Schram and G. Doekes and Jansen-van, {Vliet P. H. N.} and Janssen, {N. A. H.} and Aarts, {F. J. H.} and {de Meer}, G. and J. Crane and K. Wickens and D. Barry and W. Nystad and R. Bolle and E. Lund and Batlles, {Garrido J.} and Rubi, {Ruiz T.} and Bonillo, {Perales A.} and Gonzalez, {Jimenez Y.} and Aguirre, {Rodriguez J.} and Momblan, {deCabo J.} and Losilla, {Maldonado A.} and Daza, {Torres M.} and L. Garcia-Marcos and Martinez, {Torres A.} and Guillen, {Perez J. J.} and Pinana, {Lopez A.} and Castejon, {Robles S.} and Garcia, {Hernandez G.} and Martinez, {Gimeno A.} and Moro, {Rodriguez A. L.} and Luna, {Paredes C.} and Gonzalez, {Gil I.} and Morales, {Suarez-Varela M. M.} and Llopis, {Gonzalez A.} and Escribano, {Montaner A.} and Tallon, {Guerola M.} and L. Braback and M. Kjellman and L. Nilsson and -M., {Mai X.} and L. Braback and A. Sandin and Y. Saraclar and S. Kuyucu and A. Tuncer and C. Sackesen and V. Sumbuloglu and P. Geyik and C. Kocabas and Strachan, {D. P.} and B. Kaur and N. El-Sharif and B. Nemery and F. Barghuthy and Abu, {Huij S.} and M. Qlebo and {van Hage}, M. and N. Ait-Khaled and Anderson, {H. R.} and Strachan, {D. P.} and C. Flohr and H. Williams and F. Forastiere and I. Asher and P. Ellwood and A. Stewart and E. Mitchell and J. Crane and N. Pearce and R. Beasley and B. Bjorksten and B. Brunekreef and S. Foliaki and L. Garcia-Marcos and {von Mutius}, E. and U. Keil and Weiland, {S. K.} and G. Weinmayr and Lai, {C. K. W.} and J. Mallol and S. Montefort and J. Odhiambo and C. Robertson",

year = "2019",

doi = "10.1007/s10654-018-0463-z",

language = "English",

volume = "34",

pages = "509--520",

journal = "European Journal of Epidemiology",

issn = "0393-2990",

publisher = "Springer Netherlands",

number = "5",

}

Weinmayr, G, Jaensch, A, -K., RA, Forastiere, F, Strachan, DP, Weiland, SK, Buchele, G, Dentler, C, Jaensch, A, Rzehak, P, Weinmayr, G, Priftanji, A, Shkurti, A, Simenati, J, Grabocka, E, Shyti, K, Agolli, S, Gurakuqi, A, Stein, RT, de Pereira, MU, Jones, MH, Pitrez, PM, Cooper, PJ, Chico, M, Chen, YZ, Zhong, NS, Lai, CKW, Wong, GWK, -A., RM, Annus, T, Annesi-Maesano, I, Gotua, M, Rukhadze, M, Abramidze, T, Kvachadze, I, Karsanidze, L, Kiladze, M, Dolidze, N, Leupold, W, Keil, U, von Mutius, E, Weiland, SK, von Mutius, E, Keil, U, Weiland, SK, Arthur, P, Addo-Yobo, E, Gratziou, C, Priftis, K, Papadopoulou, A, Katsardis, C, Tsanakas, J, Hatziagorou, E, Kirvassilis, F, Clausen, M, Shah, JR, Mathur, RS, Khubchandani, RP, Mantri, S, Forastiere, F, Di, DR, De, SM, Sammarro, S, Pistelli, R, Serra, MG, Corbo, G, Perucci, CA, Svabe, V, Sebre, D, Casno, G, Novikova, I, Bagrade, L, Brunekreef, B, Schram, D, Doekes, G, Jansen-van, VPHN, Janssen, NAH, Aarts, FJH, de Meer, G, Crane, J, Wickens, K, Barry, D, Nystad, W, Bolle, R, Lund, E, Batlles, GJ, Rubi, RT, Bonillo, PA, Gonzalez, JY, Aguirre, RJ, Momblan, DJ, Losilla, MA, Daza, TM, Garcia-Marcos, L, Martinez, TA, Guillen, PJJ, Pinana, LA, Castejon, RS, Garcia, HG, Martinez, GA, Moro, RAL, Luna, PC, Gonzalez, GI, Morales, S-VMM, Llopis, GA, Escribano, MA, Tallon, GM, Braback, L, Kjellman, M, Nilsson, L, -M., MX, Braback, L, Sandin, A, Saraclar, Y, Kuyucu, S, Tuncer, A, Sackesen, C, Sumbuloglu, V, Geyik, P, Kocabas, C, Strachan, DP, Kaur, B, El-Sharif, N, Nemery, B, Barghuthy, F, Abu, HS, Qlebo, M, van Hage, M, Ait-Khaled, N, Anderson, HR, Strachan, DP, Flohr, C, Williams, H, Forastiere, F, Asher, I, Ellwood, P, Stewart, A, Mitchell, E, Crane, J, Pearce, N, Beasley, R, Bjorksten, B, Brunekreef, B, Foliaki, S, Garcia-Marcos, L, von Mutius, E, Keil, U, Weiland, SK, Weinmayr, G, Lai, CKW, Mallol, J, Montefort, S, Odhiambo, J & Robertson, C 2019, 'Can environment or allergy explain international variation in prevalence of wheeze in childhood?', European Journal of Epidemiology, vol. 34, n. 5, pagg. 509-520. https://doi.org/10.1007/s10654-018-0463-z