CagA antigen of Helicobacter pylori and coronary instability: insight from a clinico-pathological study and a meta-analysis of 4241 cases

Francesco Franceschi, Antonio Gasbarrini, Gaetano Antonio Lanza, Giovanni Battista Gasbarrini, Filippo Crea, Giampaolo Niccoli, Giuseppe Ferrante, Marcello Candelli, Nathalie Saulnier, Micaela Conte, Davide Roccarina, A Baldi, F Feroce, Sn Gentiloni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

82 Citazioni (Scopus)

Abstract

Cytotoxin-associated gene-A (CagA) antigen is expressed by some virulent strains of Helicobacter pylori (H. pylori). The role of CagA antigen in coronary instability is unknown. We performed a clinico-pathological study and a meta-analysis in the attempt to shed new light on this complex issue. METHODS: In the clinico-pathological study, 38 patients with unstable angina (UA), 25 patients with stable angina (SA), 21 patients with normal coronary arteries (NCA) and 50 age and sex matched healthy volunteers were enrolled. Serology for CagA was assessed in all patients. Specimens of atherosclerotic plaques were obtained from all patients by directional coronary atherectomy, and prepared for immunohistochemistry using anti-CagA monoclonal antibodies. The meta-analysis includes 9 studies assessing the association between seropositivity to CagA strains and acute coronary events. RESULTS: The titre of anti-CagA antibodies was significantly higher in patients with unstable angina (161+/-90 RU/ml) compared to those with stable angina (83+/-59 RU/ml p<0.02), NCA (47.3+/-29 RU/ml p<0.01) and healthy controls (73+/-69 p<0.02). Anti-CagA antibodies recognized antigens localized inside coronary atherosclerotic plaques in all specimens from both stable and unstable patients. In the meta-analysis, seropositivity to CagA was significantly associated with the occurrence of acute coronary events with an odds ratio (OR) of 1.34 (95% CI, 1.15-1.58, p=0.0003). CONCLUSIONS: Taken together these findings suggest that in a subset of patients with unstable angina, an intense immune response against CagA-positive H. pylori strains might be critical to precipitate coronary instability mediated by antigen mimicry between CagA antigen and a protein contained in coronary atherosclerotic plaques.
Lingua originaleEnglish
pagine (da-a)535-542
Numero di pagine8
RivistaATHEROSCLEROSIS
Volume202
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Aged
  • Angina, Unstable
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • Coronary Artery Disease
  • Coronary Vessels
  • Female
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Seroepidemiologic Studies

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