Caesarean section and risk of vertical transmission of HIV-1 infection. The European Collaborative Study

Marco De Santis, various members

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Indirect evidence suggests that a significant proportion of vertical transmission of HIV infection occurs late in pregnancy or during delivery. Caesarean section, therefore, may protect the fetus from infection. We looked at 1254 HIV-infected mothers and their children and the effects of different modes of delivery on transmission risk. We also included a detailed assessment of confounding factors associated with transmission risk. Women who had caesarean sections were more advanced in their disease progression which may cause the protective effect of caesarean section to be underestimated. When this and other potential confounding factors were taken into account, caesarean section was estimated to halve the rate of transmission. This finding is important in the design of studies to evaluate treatments aimed at reducing mother-to-child transmission.
Lingua originaleEnglish
pagine (da-a)1464-1467
Numero di pagine4
RivistaThe Lancet
Volume343
Stato di pubblicazionePubblicato - 1994

Keywords

  • Acquired Immunodeficiency Syndrome
  • Cesarean Section
  • Female
  • HIV-1
  • Humans
  • Infant, Newborn
  • Odds Ratio
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Risk Factors

Fingerprint

Entra nei temi di ricerca di 'Caesarean section and risk of vertical transmission of HIV-1 infection. The European Collaborative Study'. Insieme formano una fingerprint unica.

Cita questo