Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends

Paolo Montuschi, Giovanni Ciabattoni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

55 Citazioni (Scopus)


Inhaled bronchodilators, including long-acting muscarinic receptor antagonists (LAMA) and long-acting β2-adrenoreceptor agonists (LABA), are the mainstay of pharmacological treatment of stable chronic obstructive pulmonary disease (COPD). Among approved LAMA, tiotropium bromide, glycopyrronium bromide, and umeclidinium bromide are administered once daily, whereas aclidinium bromide is administered every 12 h. New LAMA are under development for COPD. Among the approved LABA, indacaterol has a 24 h duration of action, whereas salmeterol and formoterol require twice-daily administration. New once-daily LABA, including vilanterol, olodaterol, milveterol, carmoterol, and abediterol, are in development. LAMA/LABA fixed dose combinations (FDCs) provide the convenience of two bronchodilators with different mechanism of action in a single inhaler. Indacaterol/glycopyrronium, umeclidinium/vilanterol, and olodaterol/tiotropium FDCs have been approved or are under approval and are likely to become a standard pharmacological strategy for COPD. Inhaled dual-pharmacology compounds, combining muscarinic antagonism and β2-agonism (MABA) in a single molecule, potentially provide additive or synergistic bronchodilation over either inhaled antimuscarinic or β2-agonist monotherapy
Lingua originaleEnglish
pagine (da-a)4131-4164
Numero di pagine34
RivistaJournal of Medicinal Chemistry
Stato di pubblicazionePubblicato - 2015


  • Antagonisti recettoriali muscarinici inalatori a lunga durata di azione
  • Beta2-agonisti inalatori a lunga durata di azione
  • Bronchodilating drugs
  • Broncopneumopatia cronica ostruttiva
  • Chronic obstructive pulmonary disease
  • Farmaci broncodilatatori
  • Inhaled long-acting beta2 agpnists
  • Inhaled long-acting muscarinic receptor antagonists


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