Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

Vincenzo Arena, Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Edoardo Pescarmona, Anna Sapino, Irene Terrenato, Marcella Mottolese

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.
Lingua originaleEnglish
pagine (da-a)143-153
Numero di pagine11
RivistaJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • HER2, Amplification

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