Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation

Paolo Maria Rossini, Jonathan Wirsich, Marc Rey, Maxime Guye, Christian Bénar, Laura Lanteaume, Ben Ridley, Sylviane Confort-Gouny, Catherine Cassé-Perrot, Elisabeth Soulier, Patrick Viout, Franck Rouby, Marie-Noëlle Lefebvre, Christine Audebert, Romain Truillet, Elisabeth Jouve, Pierre Payoux, David Bartrés-Faz, Régis Bordet, Jill C. RichardsonClaudio Babiloni, Joelle Micallef, Olivier Blin, Jean-Philippe Ranjeva

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer’s disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative ‘PharmaCog’. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaBrain Topography
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Anatomy
  • Donepezil
  • EEG-fMRI
  • Functional connectivity
  • Memantine
  • Neurology
  • Neurology (clinical)
  • Radiological and Ultrasound Technology
  • Radiology, Nuclear Medicine and Imaging
  • Sleep

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