Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation

Lorenzo Pini; Francesca Benedetta Pizzini; Ilaria Boscolo-Galazzo; Clarissa Ferrari; Samantha Galluzzi; Maria Cotelli; Elena Gobbi; Annamaria Cattaneo; Maria Sofia Cotelli; Cristina Geroldi; Orazio Zanetti; Maurizio Corbetta; Martijn Van Den Heuvel; Giovanni Battista Frisoni; Rosa Manenti; Michela Pievani

doi:10.1016/j.neurobiolaging.2021.11.005

Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation

Lorenzo Pini, Francesca Benedetta Pizzini, Ilaria Boscolo-Galazzo, Clarissa Ferrari, Samantha Galluzzi, Maria Cotelli, Elena Gobbi, Annamaria Cattaneo, Maria Sofia Cotelli, Cristina Geroldi, Orazio Zanetti, Maurizio Corbetta, Martijn Van Den Heuvel, Giovanni Battista Frisoni, Rosa Manenti, Michela Pievani

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.

Lingua originale	English
pagine (da-a)	24-34
Numero di pagine	11
Rivista	Neurobiology of Aging
Volume	111
DOI	https://doi.org/10.1016/j.neurobiolaging.2021.11.005
Stato di pubblicazione	Pubblicato - 2022
Pubblicato esternamente	Sì

Keywords

Aged
Aged, 80 and over
Alzheimer Disease
Alzheimer's disease
Behavior
Brain
Cognition
Default mode network
Executive Function
Female
Frontotemporal Dementia
Frontotemporal dementia
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Network stimulation
Salience network
Transcranial Direct Current Stimulation

Accesso al documento

10.1016/j.neurobiolaging.2021.11.005

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Pini, L., Pizzini, F. B., Boscolo-Galazzo, I., Ferrari, C., Galluzzi, S., Cotelli, M., Gobbi, E., Cattaneo, A., Cotelli, M. S., Geroldi, C., Zanetti, O., Corbetta, M., Van Den Heuvel, M., Frisoni, G. B., Manenti, R., & Pievani, M. (2022). Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation. Neurobiology of Aging, 111, 24-34. https://doi.org/10.1016/j.neurobiolaging.2021.11.005

@article{3813846cf35d4e708c1871a03972387d,

title = "Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation",

abstract = "The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Alzheimer's disease, Behavior, Brain, Cognition, Default mode network, Executive Function, Female, Frontotemporal Dementia, Frontotemporal dementia, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Network stimulation, Salience network, Transcranial Direct Current Stimulation, Aged, Aged, 80 and over, Alzheimer Disease, Alzheimer's disease, Behavior, Brain, Cognition, Default mode network, Executive Function, Female, Frontotemporal Dementia, Frontotemporal dementia, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Network stimulation, Salience network, Transcranial Direct Current Stimulation",

author = "Lorenzo Pini and Pizzini, {Francesca Benedetta} and Ilaria Boscolo-Galazzo and Clarissa Ferrari and Samantha Galluzzi and Maria Cotelli and Elena Gobbi and Annamaria Cattaneo and Cotelli, {Maria Sofia} and Cristina Geroldi and Orazio Zanetti and Maurizio Corbetta and {Van Den Heuvel}, Martijn and Frisoni, {Giovanni Battista} and Rosa Manenti and Michela Pievani",

year = "2022",

doi = "10.1016/j.neurobiolaging.2021.11.005",

language = "English",

volume = "111",

pages = "24--34",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "[New York, NY] : Elsevier, 1980-",

}

Pini, L, Pizzini, FB, Boscolo-Galazzo, I, Ferrari, C, Galluzzi, S, Cotelli, M, Gobbi, E, Cattaneo, A, Cotelli, MS, Geroldi, C, Zanetti, O, Corbetta, M, Van Den Heuvel, M, Frisoni, GB, Manenti, R & Pievani, M 2022, 'Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation', Neurobiology of Aging, vol. 111, pagg. 24-34. https://doi.org/10.1016/j.neurobiolaging.2021.11.005

TY - JOUR

T1 - Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation

AU - Pini, Lorenzo

AU - Pizzini, Francesca Benedetta

AU - Boscolo-Galazzo, Ilaria

AU - Ferrari, Clarissa

AU - Galluzzi, Samantha

AU - Cotelli, Maria

AU - Gobbi, Elena

AU - Cattaneo, Annamaria

AU - Cotelli, Maria Sofia

AU - Geroldi, Cristina

AU - Zanetti, Orazio

AU - Corbetta, Maurizio

AU - Van Den Heuvel, Martijn

AU - Frisoni, Giovanni Battista

AU - Manenti, Rosa

AU - Pievani, Michela

PY - 2022

Y1 - 2022

N2 - The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.

AB - The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Alzheimer's disease

KW - Behavior

KW - Brain

KW - Cognition

KW - Default mode network

KW - Executive Function

KW - Female

KW - Frontotemporal Dementia

KW - Frontotemporal dementia

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Nerve Net

KW - Network stimulation

KW - Salience network

KW - Transcranial Direct Current Stimulation

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Alzheimer's disease

KW - Behavior

KW - Brain

KW - Cognition

KW - Default mode network

KW - Executive Function

KW - Female

KW - Frontotemporal Dementia

KW - Frontotemporal dementia

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Nerve Net

KW - Network stimulation

KW - Salience network

KW - Transcranial Direct Current Stimulation

UR - http://hdl.handle.net/10807/202676

U2 - 10.1016/j.neurobiolaging.2021.11.005

DO - 10.1016/j.neurobiolaging.2021.11.005

M3 - Article

SN - 0197-4580

VL - 111

SP - 24

EP - 34

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo