Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19)

Domenica Lorusso, Anna Fagotti, Giovanni Scambia, Claudia Marchetti, Gennaro Cormio, Angela Gambino, Sabrina Cecere, Ugo De Giorgi, Stefano Bogliolo, Serafina Mammoliti, Filomena Narducci, Alice Bergamini, Paolo Scollo, Nicoletta Biglia, Enrico Breda, Stefano Tamberi, Marco Marinaccio, Roberto Angioli, Laura Salerno, Maria Chiara EusebiVera Loizzi, Pierluigi Benedetti Panici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

21 Citazioni (Scopus)

Abstract

Background Brain metastases (BM) from epithelial ovarian cancer (EOC) are considered a rare and unfavourable event. There is no consensus regarding the best management of these patients. Methods A multicenter retrospective analysis of patients with BM from EOC treated between 1997 and 2014 in 18 institutions of the MITO (Multicenter Italian Trials in Ovarian cancer) group was conducted. Univariate and multivariate analysis were performed. Results A total of 174 women were identified as having BM from EOC. The median time interval between primary diagnosis of EOC and occurrence of BM was 26 months (range 2–129 months). The median overall survival from primary EOC diagnosis was 48 months (95% CI 39.5–56.4 months) and from diagnosis of BM was 12 months (95% CI 9.6–14.3 months). The majority of enrolled women (81.7%) were classified as sensitive to platinum-based chemotherapy. Four variables were significantly associated with poor overall survival in multivariate analysis: multiple BM [HR: 1.86 (95% CI: 1.22–2.84)], presence of extracranial disease [HR: 1.77 (95% CI: 1.11–2.83)] age [HR: 1.74 (95% CI: 1.17–2.59)], and monotherapy [HR: 2.57 (95% CI: 1.64–3.86)]. On the contrary, residual tumor at primary surgery, FIGO stage at primary diagnosis and platinum sensitivity were found to have no significant impact on survival from diagnosis of brain lesions. Conclusions Our results suggest that BM is a rare and late manifestation of EOC, with a 12-month life-span expectation. Multiple approach is a positive independent prognostic factor and should be proposed to carefully selected patients.
Lingua originaleEnglish
pagine (da-a)532-538
Numero di pagine7
RivistaGynecologic Oncology
Volume143
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Brain metastasis
  • Obstetrics and Gynecology
  • Oncology
  • Ovarian cancer
  • Platinum sensitivity

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