Botulinum toxin-B ultrasound-guided injections for sialorrhea in amytrophic lateral sclerosis and Parkinson's disease

Maurizio Pompili, Mario Sabatelli, Gian Ludovico Rapaccini, Giovanni Battista Gasbarrini, Anna Rita Bentivoglio, Maria Fiorella Contarino, Paola Tittoto, Pietro Attilio Tonali, Nicola Vanacore, Augusto Cedrone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Sialorrhea is frequent and invalidating in patients with amyotrophic lateral sclerosis (ALS) or Parkinson's disease (PD). Botulinum toxin (BTX) emerged as an alternative to traditional treatments. We evaluated efficacy and tolerability of ultrasound-guided BTX-B injections in parotids and submandibular glands in 18 patients with ALS or PD. At 1 week, both objective (cotton rolls weight) and subjective evaluations (dedicated clinical scales) documented sialorrhea reduction (p<0.01). ALS patients reported shorter benefit duration (p<0.001) and higher prevalence of viscous saliva (seven vs one patients), possibly due to different pattern of autonomic involvement. BTX-B seems efficacious in reducing sialorrhea in ALS and PD but the risk-benefit ratio might differ between these two conditions. This might have implications for clinical practice.
Lingua originaleEnglish
pagine (da-a)299-303
Numero di pagine5
RivistaPARKINSONISM &amp; RELATED DISORDERS
Stato di pubblicazionePubblicato - 2007

Keywords

  • Botulinum toxin
  • Parkinson disease

Fingerprint Entra nei temi di ricerca di 'Botulinum toxin-B ultrasound-guided injections for sialorrhea in amytrophic lateral sclerosis and Parkinson's disease'. Insieme formano una fingerprint unica.

Cita questo