Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

Eleonora Gaetani, Antonio Gasbarrini, L. Neri, P. Iovino, Donato Francesco Altomare, Vito Annese, Danilo Badiali, Guido Basilisco, Gabrio Bassotti, Edda Battaglia, Gabriele Bazzocchi, Massimo Bellini, Emanuele Bendia, Luigi Benini, Giuseppe Biscaglia, Ivano Biviano, Renato Bocchini, Sebastiano Bonventre, Fabrizio Bossa, Giovanni BrandimarteRenato Cannizzaro, Michele Cicala, Livio Cipolletta, Virgilio Clara, Rosanna Cogliandro, Giulia Comandini, Enrico Corazziari, Sergio Crotta, Rosario Cuomo, Lucia D'Alba, Francesco De Giorgi, Mario Del Piano, Michela Di Fonzo, Francesco Di Mario, Michele Di Stefano, Vittorio D'Onofrio, Kostantinos Efthymakis, Pierluigi Fiore, Manuela Fortuna, Walter Fries, Francesca Galeazzi, Andrea Geccherle, Francesco Giangregorio, Lisa Girardi, Mario Grassini, Marzia Groppo, Giovanni Guarnieri, Massimiliano Lo Cascio, Roberto Lolli, Francesco Luzza, Giampiero Macarri, Maria Marino, Stefania Miraglia, Santo Monastra, Maria Cristina Neri, Matteo Neri, Roberto Antonio Noris, Silvia Orselli, Sandro Passaretti, Alberto Paviotti, Paolo Pazzi, Alberto Pilotto, Piero Portincasa, Nunzio Ranaldo, Paolo Ravelli, Francesca Rogai, Renato Sablich, Vincenzo Savarino, Giancarlo Spinzi, Vincenzo Stanghellini, Leonardo Tammaro, Francesco Torresan, Paolo Usai Satta, C. Claudio Valle

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Background: The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods: Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results: The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences: Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.
Lingua originaleEnglish
pagine (da-a)581-591
Numero di pagine11
RivistaNeurogastroenterology and Motility
Volume28
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Bloating
  • Chronic constipation
  • Functional constipation
  • Irritable bowel syndrome
  • Patient-reported outcomes
  • Quality of life
  • Treatment satisfaction

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