OBJECTIVES: To compare two samples of Bipolar (BD) patients presenting "pure" (D)
and mixed (Mx) depression to assess any difference in terms of clinical outcome,
social functioning and quality of life during a 1-year follow-up.
METHODS: A total of 114 depressed outpatients (HDRS > 13) were included. "Pure"
depressed (D, n = 76) were divided from "mixed" depressed (Mx, n = 38) by the
number of concomitant manic symptoms. All patients were evaluated by the Hamilton
Depression Rating Scale (HDRS), the Hamilton Anxiety Rating Scale (HARS), the
Young Mania Rating Scale (YMRS), the Global Assessment of Functioning (GAF), the
Social Adjustment Self-reported Scale (SASS) and the Quality of Life Scale (QoL),
at baseline and after 1, 3, 6 and 12 months of treatment.
RESULTS: Mx patients were significantly younger at the onset of BD. Manic
features persisted significantly higher in Mx than in D patients all over the
follow-up period. Axis I comorbidities had a negative impact on the course of
social functioning over the medium term period, while Mx patients showed a faster
improvement in social adjustment than "pure" depressed patients.
CONCLUSIONS: Mixed features may persist relatively stable throughout a depressive
episode, having a negative impact over clinical and functional outcome, but not
on social adjustment.
- Aged, 80 and over
- Analysis of Variance
- Antidepressive Agents
- Antipsychotic Agents
- Bipolar Disorder
- Depressive Disorder
- Middle Aged
- Psychiatric Status Rating Scales
- Quality of Life
- Social Adjustment
- Young Adult