Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Silvia Farè; Serena Bertoldi; Masoumeh Meskinfam; Valentina Spoldi; M. Cristina Tanzi; Ornella Parolini

doi:10.1109/EMBC.2015.7318717

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Silvia Farè
, Serena Bertoldi
, Masoumeh Meskinfam
, Valentina Spoldi
, M. Cristina Tanzi
, Ornella Parolini

Polytechnic University of Milan
Islamic Azad University
Centro di Ricerca 'E. Menni' Fondazione Poliambulanza-Istituto Ospedaliero

Risultato della ricerca: Contributo in rivista › Articolo di conferenza

3 Citazioni (Scopus)

Abstract

A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration

Lingua originale	Inglese
pagine (da-a)	1753-1756
Numero di pagine	4
Rivista	IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS
Volume	2015
Numero di pubblicazione	n/a
DOI	https://doi.org/10.1109/EMBC.2015.7318717
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Teoria dei Segnali
Ingegneria Biomedica
Visione Artificiale e Riconoscimento di Pattern
Informatica della Salute

Keywords

Biomimetics
Cell Adhesion
Cell Differentiation
Female
Humans
Osteogenesis
Placenta
Polyurethanes
Pregnancy
Surface Properties
Tissue Scaffolds
Weight-Bearing

Accesso al documento

10.1109/EMBC.2015.7318717

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title = "Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)",

abstract = "A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration",

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author = "Silvia Far{\`e} and Serena Bertoldi and Masoumeh Meskinfam and Valentina Spoldi and Tanzi, \{M. Cristina\} and Ornella Parolini",

year = "2015",

doi = "10.1109/EMBC.2015.7318717",

language = "English",

volume = "2015",

pages = "1753--1756",

journal = "IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS",

issn = "1557-170X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "n/a",

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Farè, S, Bertoldi, S, Meskinfam, M, Spoldi, V, Tanzi, MC & Parolini, O 2015, 'Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)', IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS, vol. 2015, n. n/a, pagg. 1753-1756. https://doi.org/10.1109/EMBC.2015.7318717

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC). / Farè, Silvia; Bertoldi, Serena; Meskinfam, Masoumeh et al.
In: IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS, Vol. 2015, N. n/a, 2015, pag. 1753-1756.

Risultato della ricerca: Contributo in rivista › Articolo di conferenza

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AU - Farè, Silvia

AU - Bertoldi, Serena

AU - Meskinfam, Masoumeh

AU - Spoldi, Valentina

AU - Tanzi, M. Cristina

AU - Parolini, Ornella

PY - 2015

Y1 - 2015

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AB - A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration

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KW - Female

KW - Humans

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KW - Placenta

KW - Polyurethanes

KW - Pregnancy

KW - Surface Properties

KW - Tissue Scaffolds

KW - Weight-Bearing

KW - Biomimetics

KW - Cell Adhesion

KW - Cell Differentiation

KW - Female

KW - Humans

KW - Osteogenesis

KW - Placenta

KW - Polyurethanes

KW - Pregnancy

KW - Surface Properties

KW - Tissue Scaffolds

KW - Weight-Bearing

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JO - IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS

JF - IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS

IS - n/a

ER -

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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