Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Ornella Parolini, Silvia Fare, Serena Bertoldi, Masoumeh Meskinfam, Valentina Spoldi, M. Cristina Tanzi

Risultato della ricerca: Contributo in rivistaContributo a convegno

3 Citazioni (Scopus)

Abstract

A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration
Lingua originaleEnglish
pagine (da-a)1753-1756
Numero di pagine4
RivistaIEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS
Volume2015
DOI
Stato di pubblicazionePubblicato - 2015
Evento37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - MILANO -- ITA
Durata: 25 ago 201529 ago 2015

Keywords

  • Biomimetics
  • Cell Adhesion
  • Cell Differentiation
  • Female
  • Humans
  • Osteogenesis
  • Placenta
  • Polyurethanes
  • Pregnancy
  • Surface Properties
  • Tissue Scaffolds
  • Weight-Bearing

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