Biomechanical investigation of colorectal cancer cells

Valentina Palmieri; Donatella Lucchetti; Alessandro Maiorana; Massimiliano Papi; Giuseppe Maulucci; Gabriele Ciasca; Maria Svelto; Marco De Spirito; Alessandro Sgambato

doi:10.1063/1.4896161

Biomechanical investigation of colorectal cancer cells

Valentina Palmieri
, Donatella Lucchetti
, Alessandro Maiorana
, Massimiliano Papi^*
, Giuseppe Maulucci
, Gabriele Ciasca
, Maria Svelto
, Marco De Spirito
, Alessandro Sgambato

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo › peer review

28 Citazioni (Scopus)

Abstract

The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Applied Physics Letters
Volume	105
Numero di pubblicazione	12
DOI	https://doi.org/10.1063/1.4896161
Stato di pubblicazione	Pubblicato - 2014

All Science Journal Classification (ASJC) codes

Fisica e Astronomia (varie)

Keywords

adhesion
inglese

OSS delle Nazioni Unite

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abstract = "The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.",

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AU - Palmieri, Valentina

AU - Lucchetti, Donatella

AU - Maiorana, Alessandro

AU - Papi, Massimiliano

AU - Maulucci, Giuseppe

AU - Ciasca, Gabriele

AU - Svelto, Maria

AU - De Spirito, Marco

AU - Sgambato, Alessandro

PY - 2014

Y1 - 2014

N2 - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

AB - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

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KW - inglese

KW - adhesion

KW - inglese

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VL - 105

SP - N/A-N/A

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IS - 12

ER -

Biomechanical investigation of colorectal cancer cells

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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