Biomechanical investigation of colorectal cancer cells

Valentina Palmieri; Donatella Lucchetti; Alessandro Maiorana; Massimiliano Papi; Giuseppe Maulucci; Gabriele Ciasca; Maria Svelto; Marco De Spirito; Alessandro Sgambato

doi:10.1063/1.4896161

Biomechanical investigation of colorectal cancer cells

Valentina Palmieri, Donatella Lucchetti, Alessandro Maiorana, Massimiliano Papi, Giuseppe Maulucci, Gabriele Ciasca, Maria Svelto, Marco De Spirito, Alessandro Sgambato

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

28 Citazioni (Scopus)

Abstract

The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Applied Physics Letters
Volume	105
DOI	https://doi.org/10.1063/1.4896161
Stato di pubblicazione	Pubblicato - 2014

Keywords

adhesion
inglese

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title = "Biomechanical investigation of colorectal cancer cells",

abstract = "The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.",

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author = "Valentina Palmieri and Donatella Lucchetti and Alessandro Maiorana and Massimiliano Papi and Giuseppe Maulucci and Gabriele Ciasca and Maria Svelto and {De Spirito}, Marco and Alessandro Sgambato",

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doi = "10.1063/1.4896161",

language = "English",

volume = "105",

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TY - JOUR

T1 - Biomechanical investigation of colorectal cancer cells

AU - Palmieri, Valentina

AU - Lucchetti, Donatella

AU - Maiorana, Alessandro

AU - Papi, Massimiliano

AU - Maulucci, Giuseppe

AU - Ciasca, Gabriele

AU - Svelto, Maria

AU - De Spirito, Marco

AU - Sgambato, Alessandro

PY - 2014

Y1 - 2014

N2 - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

AB - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

KW - adhesion

KW - inglese

KW - adhesion

KW - inglese

UR - http://hdl.handle.net/10807/63008

U2 - 10.1063/1.4896161

DO - 10.1063/1.4896161

M3 - Article

SN - 1077-3118

VL - 105

SP - N/A-N/A

JO - Applied Physics Letters

JF - Applied Physics Letters

ER -

Biomechanical investigation of colorectal cancer cells

Abstract

Keywords

OSS delle Nazioni Unite

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