TY - JOUR
T1 - Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
AU - Romano, A.
AU - Del, Vescovo E.
AU - Rivetti, S.
AU - Triarico, S.
AU - Attina, G.
AU - Mastrangelo, Stefano
AU - Maurizi, Palma
AU - Ruggiero, Antonio
PY - 2022
Y1 - 2022
N2 - The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent long-term side effects, and causes high mortality and morbidity. Consequently, it is necessary to identify strategies that allow for early diagnosis. In this review, the pathogenetic mechanisms of metabolic syndrome and the potential new biomarkers that can facilitate its diagnosis in survivors of pediatric tumors are analyzed.
AB - The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent long-term side effects, and causes high mortality and morbidity. Consequently, it is necessary to identify strategies that allow for early diagnosis. In this review, the pathogenetic mechanisms of metabolic syndrome and the potential new biomarkers that can facilitate its diagnosis in survivors of pediatric tumors are analyzed.
KW - cancer survivors
KW - cardiovascular disease
KW - chemotherapy toxicity
KW - childhood cancer
KW - metabolic syndrome
KW - obesity
KW - radiotherapy toxicity
KW - cancer survivors
KW - cardiovascular disease
KW - chemotherapy toxicity
KW - childhood cancer
KW - metabolic syndrome
KW - obesity
KW - radiotherapy toxicity
UR - https://publicatt.unicatt.it/handle/10807/223516
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85131378182&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131378182&origin=inward
U2 - 10.3390/jpm12060880
DO - 10.3390/jpm12060880
M3 - Article
SN - 2075-4426
VL - 12
SP - N/A-N/A
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 6
ER -
