TY - JOUR
T1 - Biomarkers for sarcopenia: Reductionism vs. complexity
AU - Calvani, Riccardo
AU - Picca, A.
AU - Cesari, M.
AU - Tosato, M.
AU - Marini, F.
AU - Manes-Gravina, E.
AU - Bernabei, R.
AU - Landi, Francesco
AU - Marzetti, Emanuele
PY - 2018
Y1 - 2018
N2 - Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers. This review summarizes the current knowledge on biological markers for sarcopenia, including a critical appraisal of traditional procedures for biomarker development in the field of muscle aging. As an alternative approach, we illustrate the potential advantages of biomarker discovery procedures based on multivariate methodologies. Relevant examples of multidimensional biomarker modeling are provided with an emphasis on its clinical and research application.
AB - Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers. This review summarizes the current knowledge on biological markers for sarcopenia, including a critical appraisal of traditional procedures for biomarker development in the field of muscle aging. As an alternative approach, we illustrate the potential advantages of biomarker discovery procedures based on multivariate methodologies. Relevant examples of multidimensional biomarker modeling are provided with an emphasis on its clinical and research application.
KW - Disability
KW - Frailty
KW - Markers
KW - Multivariate analysis
KW - Physical performance
KW - Skeletal muscle
KW - Disability
KW - Frailty
KW - Markers
KW - Multivariate analysis
KW - Physical performance
KW - Skeletal muscle
UR - https://publicatt.unicatt.it/handle/10807/220672
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85048882211&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048882211&origin=inward
U2 - 10.2174/1389203718666170516115422
DO - 10.2174/1389203718666170516115422
M3 - Article
SN - 1389-2037
VL - 19
SP - 639
EP - 642
JO - Current Protein and Peptide Science
JF - Current Protein and Peptide Science
IS - 7
ER -