Biomarkers for sarcopenia: Reductionism vs. complexity

Riccardo Calvani, Anna Picca, Matteo Cesari, Matteo Tosato, Federico Marini, Ester Manes-Gravina, Roberto Bernabei, Francesco Landi, Emanuele Marzetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers. This review summarizes the current knowledge on biological markers for sarcopenia, including a critical appraisal of traditional procedures for biomarker development in the field of muscle aging. As an alternative approach, we illustrate the potential advantages of biomarker discovery procedures based on multivariate methodologies. Relevant examples of multidimensional biomarker modeling are provided with an emphasis on its clinical and research application.
Lingua originaleEnglish
pagine (da-a)639-642
Numero di pagine4
RivistaCURRENT PROTEIN & PEPTIDE SCIENCE
Volume19
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Disability
  • Frailty
  • Markers
  • Multivariate analysis
  • Physical performance
  • Skeletal muscle

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