Abstract
The adoption of a biomimetic approach in the
design and fabrication of innovative materials for biomedical
applications is encountering a growing interest. In particular,
new molecules are being engineered on the basis of proteins
present in the extracellular matrix, such as fibronectin,
collagen, or elastin. Following this approach scientists expect
to be able not only to obtain materials with tailored
mechanical properties but also to elicit specific biological
responses inherited by the mimicked tissue. In the present
work, a novel peptide, engineered starting from the sequence encoded by exon 28 of human tropoelastin, was characterized from
a chemical, physical, and biological point of view. The obtained molecule was observed to aggregate at high temperatures,
forming a material able to induce a biological effect similar to what elastin does in the physiological context. This material seems
to be a good candidate to play a relevant role in future biomedical applications with special reference to vascular surgery.
Lingua originale | English |
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pagine (da-a) | 15898-15906 |
Numero di pagine | 9 |
Rivista | Langmuir |
Volume | 29 |
DOI | |
Stato di pubblicazione | Pubblicato - 2013 |
Keywords
- Elastin
- Tissue Engineering