Bioactivity of Phytosterols and Their Production in Plant in Vitro Cultures

Begona Miras-Moreno, Maria Begona Miras Moreno, Ana Belén Sabater-Jara, M. A. Pedreno, Lorena Almagro

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Phytosterols are a kind of plant metabolite belonging to the triterpene family. These compounds are essential biomolecules for human health, and so they must be taken from foods. β-Sitosterol, campesterol, and stigmasterol are the main phytosterols found in plants. Phytosterols have beneficial effects on human health since they are able to reduce plasma cholesterol levels and have antiinflammatory, antidiabetic, and anticancer activities. However, there are many difficulties in obtaining them, since the levels of these compounds produced from plant raw materials are low and their chemical synthesis is not economically profitable for commercial exploitation. A biotechnological alternative for their production is the use of plant cell and hairy root cultures. This review is focused on the biosynthesis of phytosterols and their function in both plants and humans as well as the different biotechnological strategies to increase phytosterol biosynthesis. Special attention is given to describing new methodologies based on the use of recombinant DNA technology to increase the levels of phytosterols.
Lingua originaleEnglish
pagine (da-a)7049-7058
Numero di pagine10
RivistaJournal of Agricultural and Food Chemistry
Stato di pubblicazionePubblicato - 2016


  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Biological Availability
  • Biotechnology
  • Cholesterol
  • Empirical Research
  • Humans
  • Hypoglycemic Agents
  • Phytosterols
  • Plant Cells
  • Plants
  • Sitosterols
  • Stigmasterol
  • biosynthethic pathway
  • in vitro cultures
  • phytosterols


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