Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass

Lydia-Ann Harris, Brandon D. Kayser, Consuelo Cefalo, Luca Marini, Jeramie D. Watrous, Jeffrey Ding, Mohit Jain, Jeffrey G. Mcdonald, Bonne M. Thompson, Elisa Fabbrini, J. Christopher Eagon, Bruce W. Patterson, Bettina Mittendorfer, Geltrude Mingrone, Samuel Klein

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


Diabetes remission is greater after biliopancreatic diversion (BPD) than Roux-en-Y gastric bypass (RYGB) surgery. We used a mixed-meal test with ingested and infused glucose tracers and the hyperinsulinemic-euglycemic clamp procedure with glucose tracer infusion to assess the effect of 20% weight loss induced by either RYGB or BPD on glucoregulation in people with obesity ( number: NCT03111953). The rate of appearance of ingested glucose into the circulation was much slower, and the postprandial increases in plasma glucose and insulin concentrations were markedly blunted after BPD compared to after RYGB. Insulin sensitivity, assessed as glucose disposal rate during insulin infusion, was ∼45% greater after BPD than RYGB, whereas β cell function was not different between groups. These results demonstrate that compared with matched-percentage weight loss induced by RYGB, BPD has unique beneficial effects on glycemic control, manifested by slower postprandial glucose absorption, blunted postprandial plasma glucose and insulin excursions, and greater improvement in insulin sensitivity.
Lingua originaleEnglish
pagine (da-a)855-864.e3
Numero di pagine10
RivistaCell Metabolism
Stato di pubblicazionePubblicato - 2019


  • bariatric surgery
  • insulin sensitivity
  • obesity


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