Bile acid content of gallbladder bile and stones in type IIb and IV hyperlipoproteinemia

Geltrude Mingrone, Av Greco, S. Passi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

We examined the bile acid composition of gallbladder bile using reversed-phase high performance liquid chromatography (HPLC), in normolipemic and hyperlipidemic (types IIb and IV) patients with cholelithiasis and compared them with normal subjects. Similarly, bile acid composition was determined n the gallstones of these patients. No free bile acids were found in any of the samples examined. We observed that gallbladder bile and gallstones of patients with type IV hyperlipidemia showed a significant increase in the percentage of glyco-conjugated bile acids and reduction in taurine conjugates. Based on this finding we postulate that in addition to biliary lipid composition bile acid composition may also play a role in the pathogenesis of cholesterol gallstone formation.
Lingua originaleEnglish
pagine (da-a)81-89
Numero di pagine9
RivistaClinica Chimica Acta
Volume116
Stato di pubblicazionePubblicato - 1981

Keywords

  • Adult
  • Bile
  • Bile Acids and Salts
  • Cholelithiasis
  • Gallbladder
  • Humans
  • Hyperlipoproteinemia Type II
  • Hyperlipoproteinemia Type IV
  • Male
  • Middle Aged

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