Bilateral symmetry of visual function loss in cone–rod dystrophies

Benedetto Falsini, Angelo Maria Minnella, Giuseppe De Rossi, Marco Piccardi, Lucia Ziccardi, Dario Marangoni, Giorgio Placidi, Francesca Campagna, Edoardo Abed, Lucia Galli-Resta, Giuseppe Rossi, Antonello Fadda, Matteo Bertelli, Monia Zuntini, Giovanni Resta

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6 Citazioni (Scopus)

Abstract

PURPOSE. To investigate bilateral symmetry of visual impairment in cone–rod dystrophy (CRD) patients and understand the feasibility of clinical trial designs treating one eye and using the untreated eye as an internal control. METHODS. This was a retrospective study of visual function loss measures in 436 CRD patients followed at the Ophthalmology Department of the Catholic University in Rome. Clinical measures considered were best-corrected visual acuity, focal macular cone electroretinogram (fERG), and Ganzfeld cone-mediated and rod-mediated electroretinograms. Interocular agreement in each of these clinical indexes was assessed by t- and Wilcoxon tests for paired samples, structural (Deming) regression analysis, and intraclass correlation. Baseline and follow-up measures were analyzed. A separate analysis was performed on the subset of 61 CRD patients carrying likely disease-causing mutations in the ABCA4 gene. RESULTS. Statistical tests show a very high degree of bilateral symmetry in the extent and progression of visual impairment in the fellow eyes of CRD patients. CONCLUSIONS. These data contribute to a better understanding of CRDs and support the feasibility of clinical trial designs involving unilateral eye treatment with the use of fellow eye as internal control.
Lingua originaleEnglish
pagine (da-a)3759-3768
Numero di pagine10
RivistaINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume57
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Cellular and Molecular Neuroscience
  • Cone dystrophy
  • Electroretinography
  • Interocular
  • Ophthalmology
  • Sensory Systems
  • Visual acuity
  • Visual function

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