Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype

Pierluigi Navarra, Roberto Cauda, Silvia Arancia, C Calugi, A Trabocchi, F De Bernardis, A Cassone, A. Guarna

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

The in vitro screening of stereoisomeric bicyclic peptidomimetics towards SAP2 of Candida albicans revealed a constrained chemotype as aspartic protease inhibitor in the micromolar to nanomolar range. The results indicated that the acetal bridge may serve as a transition-state isostere, and that the right match between interactions with subsites and the orientation by hydrogen bonding with Gly85 is the main requisite for inhibitory activity. Molecular docking calculations suggested the bicyclic acetal scaffold to be capable of interacting with the two catalytic aspartic acids, thus resulting in good inhibitory activity with only two hydrophobic groups addressing the enzyme catalytic subsites.
Lingua originaleEnglish
pagine (da-a)7206-7213
Numero di pagine8
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume20
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Candida albicans
  • bicylcic peptidomimetics

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