Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells

Gabriella Calviello, Simona Serini, Paola Palozza, Franco Oreste Ranelletti, Nicola Maggiano, P Lanza, Gm Bartoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

This is the first report demonstrating a relationship between apoptosis induction and changes of intracellular redox potential in the growth-inhibitory effects of high concentrations of beta-carotene in a tumor cell line. beta-Carotene inhibited the growth of human WiDr colon adenocarcinoma cells in a dose- and time-dependent manner, induced apoptosis, and blocked Bcl-2 expression. These effects were accompanied by an enhanced production of intracellular reactive oxygen species (ROS). The addition of the antioxidant alpha-tocopherol blocked both the pro-oxidant and the growth-inhibitory effects of the carotenoid. These findings suggest that beta-carotene may act as an inductor of apoptosis by its pro-oxidant properties
Lingua originaleEnglish
pagine (da-a)1000-1007
Numero di pagine8
RivistaFREE RADICAL BIOLOGY & MEDICINE
Stato di pubblicazionePubblicato - 2001

Keywords

  • apoptosis
  • beta carotene

Fingerprint

Entra nei temi di ricerca di 'Beta-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells'. Insieme formano una fingerprint unica.

Cita questo