Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr cells

Gabriella Calviello, Paola Palozza, Franco Oreste Ranelletti, Nicola Maggiano, P Lanza, Gm Bartoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The effects of combinations between eicosapentaenoic acid (EPA) and beta-carotene on cell growth and lipid peroxidation were investigated in human WiDr colon adenocarcinoma cells. EPA alone was able to inhibit the growth of WiDr cells in a dose- and time-dependent manner. Such an inhibition involved fatty acid peroxidation, as shown by the remarkable increase in the levels of Malondialdehyde (MDA) in EPA-treated cells. Beta-carotene was capable of reducing the growth inhibitory effects of EPA and the levels of MDA in a dose- and a time-dependent manner. In addition, EPA increased beta-carotene consumption in WiDr cells. This study provides evidence that beta-carotene can antagonize the effects of EPA on colon cancer cell growth and lipid peroxidation.
Lingua originaleEnglish
pagine (da-a)228-234
Numero di pagine7
RivistaFREE RADICAL BIOLOGY & MEDICINE
Stato di pubblicazionePubblicato - 2000

Keywords

  • beta carotene
  • eicosapentaenoic acid

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