Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

Ruggero De Maria Marchiano, Dante Rotili, Giorgia Botta, Ettore Novellino, Domenico Tarantino, Vincenzo Carafa, Chantal Paolini, Jörg Schemies, Manfred Jung, Salvatore Di Maro, Christian Steinkühler, Paola Gallinari, Lucia Altucci, Antonello Mai

Risultato della ricerca: Contributo in rivistaArticolo in rivista

24 Citazioni (Scopus)

Abstract

Inhibition of sirtuins has recently been proposed as a promising anticancer strategy. Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence. © 2012 American Chemical Society.
Lingua originaleEnglish
pagine (da-a)8193-8197
Numero di pagine5
RivistaJournal of Medicinal Chemistry
Volume55
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Antineoplastic Agents
  • Apoptosis
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Drug Discovery3003 Pharmaceutical Science
  • Flavins
  • Histone Deacetylase Inhibitors
  • Humans
  • Medicine (all)
  • Molecular Medicine
  • Neoplastic Stem Cells
  • Sirtuins

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