Abstract
Inhibition of sirtuins has recently been proposed as a promising anticancer strategy. Some of the new benzodeazaoxaflavins (2a, 2b, and 2d) here reported as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells and, most importantly, together with the prototype MC2141 (1) displayed antiproliferative effects in cancer stem cells from patients with colorectal carcinoma and glioblastoma multiforme, known to be highly tumorigenic, resistant to conventional cancer chemotherapy, and responsible, at least in part, for cancer relapse or recurrence. © 2012 American Chemical Society.
Lingua originale | English |
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pagine (da-a) | 8193-8197 |
Numero di pagine | 5 |
Rivista | Journal of Medicinal Chemistry |
Volume | 55 |
DOI | |
Stato di pubblicazione | Pubblicato - 2012 |
Keywords
- Antineoplastic Agents
- Apoptosis
- Cell Cycle
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Drug Discovery3003 Pharmaceutical Science
- Flavins
- Histone Deacetylase Inhibitors
- Humans
- Medicine (all)
- Molecular Medicine
- Neoplastic Stem Cells
- Sirtuins