Beams Arrangement in Non-Small Cell Lung Cancer (NSCLC) According to PTV and Dosimetric Parameters Predictive of Pneumonitis

Maria Antonietta Gambacorta, Francesco Cellini, Gerardina Stimato, Angelo Piermattei, Alfredo Cesario, Sara Ramella, Lucio Trodella, Tommaso Claudio Mineo, Eugenio Pompeo, Marzia Ciresa, Michele Fiore, Carlo Greco, Diego Gaudino, Rolando M. D'Angelillo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The aim of this study is to propose and validate an original new class of solutions for three-dimensional conformal radiation therapy (3DCRT) treatment planning for non-small cell lung cancer (NSCLC) according to the different patterns of disease presentation (on the basis of tumor location and volume) and to explore beams arrangement (planar or no-planar solutions) to respect dose constraints to the lung parenchyma. Benchmarks matched to validate the new approach are interuser reproducibility and saving on planning time. Tumor location was explored and specific categories created according to the tumor volume and location. Therefore, by applying planar and no-planar 3D plans, we searched for an optimization of the beams arrangement for each category. Dose-volume histograms (DVHs) were analyzed and a plan comparison performed. Results were then validated (class solution planning confirmation) by applying the same strategy to another group of patients. This has been realized at two dose levels (50.4 and 59.4 Gy). Fifty-nine patients were enrolled in this dosimetric study. In the first 27 patients ("exploratory sample") three main planning target volume location categories were identified according to the pattern of the disease presentation: (1) centrally located; (2) peripheral T and mediastinal N (P+N); and (3) superior sulcus. Original class solutions were proposed for each location category. On the next 32 patients ("validation sample"), the treatment planning started directly with the recommended approach. Mean V20Gy value was 18.8% (SD ± 7.25); mean V30Gy:12% (SD ± 4.05); and mean lung dose: 11.6Gy (SD ± 5.77). No differences between the two total dose level groups were observed. These results suggest a simple and reproducible tool for treatment planning in NSCLC, allowing interuser reproducibility and cutting down on planning time. © 2010 American Association of Medical Dosimetrists.
Lingua originaleEnglish
pagine (da-a)169-178
Numero di pagine10
RivistaMedical Dosimetry
Volume35
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Beams arrangement
  • Tumor volume
  • Radiotherapy planning
  • NSCLC

Fingerprint

Entra nei temi di ricerca di 'Beams Arrangement in Non-Small Cell Lung Cancer (NSCLC) According to PTV and Dosimetric Parameters Predictive of Pneumonitis'. Insieme formano una fingerprint unica.

Cita questo