TY - JOUR
T1 - Baseline systemic inflammatory status and no-reflow phenomenon after percutaneous coronary angioplasty for acute myocardial infarction
AU - Niccoli, Giampaolo
AU - Lanza, Gaetano Antonio
AU - Spaziani, Cristina
AU - Altamura, Luca
AU - Romagnoli, Elisa
AU - Leone, Antonio Maria
AU - Fusco, Beatrice
AU - Trani, Carlo
AU - Burzotta, Francesco
AU - Mazzari, Mario Attilio
AU - Mongiardo, Rocco
AU - Biasucci, Luigi Marzio
AU - Rebuzzi, Antonio Giuseppe
AU - Crea, Filippo
PY - 2007
Y1 - 2007
N2 - Background: Systemic inflammation is involved in several pathological cardiovascular processes. However, whether it plays a role in the no-reflow phenomenon occurring in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) is unknown. Methods: We studies 60 consecutive patients (59.5 ± 12 years, 82% males) with a first ST-segment elevation AMI, treated by primary or rescue PCI within 6 h of symptom onset. Angiographic indexes of no-reflow, evaluated at the end of the procedure, included coronary TIMI flow grading, corrected TIMI frame count (c-TFC) and myocardial blush grade (MBG). ECG indexes of no-reflow included the lack of ST segment resolution (defined as a reduction < 50% of the measured ST-segment elevation at 90 min, compared to the admission ECG), as analyzed both in the single lead with the maximal ST elevation and in all leads showing ST elevation on admission. Patients were divided into two groups according to baseline high-sensitivity C-reactive protein (CRP) serum levels measured on admission: high CRP group (CRP > 5 mg/L) and low CRP group (CRP < 5 mg/L). Results: A similar prevalence of final TIMI flow < 3 and MBG < 3 was observed in patients with high and low CRP serum levels (30% vs. 12%, p = 0.1, and 50% vs. 53%, p = 1.0, respectively), and c-TFC was also similar in the two groups (26 ± 4.5 vs. 24 ± 6, p = 0.5). Accordingly, the prevalence of lack of ST-segment resolution in the two groups was similar, both by the single-lead method (25% vs. 25%, p = 1.0) and the multiple-lead method (29% vs. 19%, p = 0.4). Conclusion: In this study we failed to demonstrate any significant association between CRP serum levels on admission and coronary no-reflow, as assessed by both angiographic and ECG parameters in AMI patients treated by successful primary or rescue PCI within 6 h of chest pain onset. © 2006 Elsevier Ireland Ltd. All rights reserved.
AB - Background: Systemic inflammation is involved in several pathological cardiovascular processes. However, whether it plays a role in the no-reflow phenomenon occurring in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) is unknown. Methods: We studies 60 consecutive patients (59.5 ± 12 years, 82% males) with a first ST-segment elevation AMI, treated by primary or rescue PCI within 6 h of symptom onset. Angiographic indexes of no-reflow, evaluated at the end of the procedure, included coronary TIMI flow grading, corrected TIMI frame count (c-TFC) and myocardial blush grade (MBG). ECG indexes of no-reflow included the lack of ST segment resolution (defined as a reduction < 50% of the measured ST-segment elevation at 90 min, compared to the admission ECG), as analyzed both in the single lead with the maximal ST elevation and in all leads showing ST elevation on admission. Patients were divided into two groups according to baseline high-sensitivity C-reactive protein (CRP) serum levels measured on admission: high CRP group (CRP > 5 mg/L) and low CRP group (CRP < 5 mg/L). Results: A similar prevalence of final TIMI flow < 3 and MBG < 3 was observed in patients with high and low CRP serum levels (30% vs. 12%, p = 0.1, and 50% vs. 53%, p = 1.0, respectively), and c-TFC was also similar in the two groups (26 ± 4.5 vs. 24 ± 6, p = 0.5). Accordingly, the prevalence of lack of ST-segment resolution in the two groups was similar, both by the single-lead method (25% vs. 25%, p = 1.0) and the multiple-lead method (29% vs. 19%, p = 0.4). Conclusion: In this study we failed to demonstrate any significant association between CRP serum levels on admission and coronary no-reflow, as assessed by both angiographic and ECG parameters in AMI patients treated by successful primary or rescue PCI within 6 h of chest pain onset. © 2006 Elsevier Ireland Ltd. All rights reserved.
KW - Acute myocardial infarction
KW - Angioplasty, Balloon, Coronary
KW - C-reactive protein
KW - Female
KW - Humans
KW - Inflammation
KW - Male
KW - Middle Aged
KW - Myocardial Infarction
KW - No-reflow
KW - Treatment Failure
KW - Acute myocardial infarction
KW - Angioplasty, Balloon, Coronary
KW - C-reactive protein
KW - Female
KW - Humans
KW - Inflammation
KW - Male
KW - Middle Aged
KW - Myocardial Infarction
KW - No-reflow
KW - Treatment Failure
UR - http://hdl.handle.net/10807/169802
U2 - 10.1016/j.ijcard.2006.05.012
DO - 10.1016/j.ijcard.2006.05.012
M3 - Article
SN - 0167-5273
VL - 117
SP - 306
EP - 311
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -