Baseline, procedural and outcome features of patients undergoing transcatheter aortic valve implantation according to different body mass index categories

Nicola Corcione, Alberto Testa, Paolo Ferraro, Alberto Morello, Michele Cimmino, Michele Albanese, Salvatore Giordano, Francesco Bedogni, Alessandro Iadanza, Sergio Berti, Damiano Regazzoli, Carlo Trani, Martino Pepe, Giacomo Frati, Giuseppe Biondi Zoccai, Arturo Giordano

Risultato della ricerca: Contributo in rivistaArticolo in rivista


BACKGROUND: Transcatheter aortic valve implantation (TAVI) has become first-line treatment for severe aortic valve stenosis in patients with moderate, high or prohibitive surgical risk.. However, access site complications may occur more frequently in such extreme body mass index (BMI) categories,. We aimed at describing features and outcomes of patients undergoing TAVI in a comprehensive Italian prospective clinical registry.METHODS: A national prospective database was queried for baseline, procedural, and outcome details of patients undergoing TAVI according to established BMI classes: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2), and obese (BMI ≥30 kg/m2). Short- and long-term outcomes, including major adverse events (MAE), i.e. the composite of death, stroke, myocardial infarction, major vascular complication, major bleeding, or renal failure, were appraised with bivariate and multivariable analyses.RESULTS: A total of 3075 subjects were included, 64 (2.1%) were underweight, 1319 (42.9%) were normal weight, 1152 (37.4%) were overweight, and 540 (17.6%) were obese. Several baseline differences were evident, including gender, diabetes mellitus, renal function, chronic obstructive pulmonary disease, surgical scores, and left ventricular ejection fraction (LVEF) (all p<0.05). Several procedural differences were also evident, including percutaneous approach, predilation, prosthesis type and size (all p<0.05), with postprocedura aortic regurgitation >2+ significantly more common in underweight patients (p<0.05). Nonetheless, unadjusted analysis for one-month outcomes showed similar rates for fatal and non-fatal outcomes, including MAE (all p>0.05), with the notable exception of permanent pacemaker implantation, which was more common in higher BMI classes (p=0.010) Unadjusted analysis for long-term events showed an increased rate of death in underweight patients (p=0.024). Multivariable adjusted analysis confirmed the increased risk of permanent pacemaker implantation in obese patients (p=0.015 when comparing obese vs normal weight subjects), but disproved differences in mortality (p>0.05 for all comparisons).CONCLUSIONS: Irrespective of BMI class, TAVI is associated with favorable outcomes in surgical high-risk risk patients, with the notable exclusion of permanent pacemaker implantation, which is significantly more common in obese subjects.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaMinerva Medica
Stato di pubblicazionePubblicato - 2021


  • BMI
  • aortic valve implantation
  • high-risk patients
  • tavi


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