TY - JOUR
T1 - Bariatric surgery in prospective obese living kidney donors: scoping review and management decision algorithm
AU - Paoletti, Fabio
AU - Urciuoli, Irene
AU - Romagnoli, Jacopo
AU - Bellini, Maria Irene
PY - 2024
Y1 - 2024
N2 - iNTrODuCTiON: global chronic kidney disease is now epidemic, with substantial health and economic consequences. While scientific support for living donor renal transplants (LDRT) is strong, donor shortages necessitate consideration of expanded criteria, including obese individuals. Bariatric surgery (BS) may mitigate obesity-related risks, but research on living donor candidates is scarce. Our scoping review aims to compile evidence, identify gaps, and formulate an algorithm to guide healthcare professionals in evaluating BS for obese living donors. eViDeNCe aCQuiSiTiON: We did a systematic search of studies on living kidney donors and obesity. We searched the MeDLiNe Ovid, embase Ovid, CeNTraL and Web of Science databases for studies from database inception to March 30, 2023. all english-language articles available in full text have been considered. excluded are commentaries, editorials, letters, and abstracts. eViDeNCe SyNTHeSiS: Obesity in LDrT raises long-term eSrD risk. Current high BMi donor admission raises ethical and clinical concerns. encouraging timely weight loss can make obese candidates suitable donors, reducing risks. Sleeve gastrectomy is the most reported and preferable approach, since it minimizes hyperoxaluria risk. re-evaluation for donation is possible 6-12 months post-BS, with BMI<35 for three months. Cost-benefit analysis favors BS over nephrectomy in obese donors (cost-benefit ratio: 3.64) when graft survival is equal. CONCLuSiONS: BS shows promise with short-term effectiveness and potential long-term outcomes. However, it should not be perceived as a means to expand the donor pool but rather as a personalized approach to address obesity and improve individuals’ health.
AB - iNTrODuCTiON: global chronic kidney disease is now epidemic, with substantial health and economic consequences. While scientific support for living donor renal transplants (LDRT) is strong, donor shortages necessitate consideration of expanded criteria, including obese individuals. Bariatric surgery (BS) may mitigate obesity-related risks, but research on living donor candidates is scarce. Our scoping review aims to compile evidence, identify gaps, and formulate an algorithm to guide healthcare professionals in evaluating BS for obese living donors. eViDeNCe aCQuiSiTiON: We did a systematic search of studies on living kidney donors and obesity. We searched the MeDLiNe Ovid, embase Ovid, CeNTraL and Web of Science databases for studies from database inception to March 30, 2023. all english-language articles available in full text have been considered. excluded are commentaries, editorials, letters, and abstracts. eViDeNCe SyNTHeSiS: Obesity in LDrT raises long-term eSrD risk. Current high BMi donor admission raises ethical and clinical concerns. encouraging timely weight loss can make obese candidates suitable donors, reducing risks. Sleeve gastrectomy is the most reported and preferable approach, since it minimizes hyperoxaluria risk. re-evaluation for donation is possible 6-12 months post-BS, with BMI<35 for three months. Cost-benefit analysis favors BS over nephrectomy in obese donors (cost-benefit ratio: 3.64) when graft survival is equal. CONCLuSiONS: BS shows promise with short-term effectiveness and potential long-term outcomes. However, it should not be perceived as a means to expand the donor pool but rather as a personalized approach to address obesity and improve individuals’ health.
KW - Bariatric surgery
KW - Body Mass index
KW - Obesity
KW - Living donors
KW - Kidney transplantation
KW - Bariatric surgery
KW - Body Mass index
KW - Obesity
KW - Living donors
KW - Kidney transplantation
UR - http://hdl.handle.net/10807/297372
U2 - 10.23736/S2724-5691.23.10128-6
DO - 10.23736/S2724-5691.23.10128-6
M3 - Article
SN - 2724-5438
VL - 79
SP - 197
EP - 209
JO - Minerva Surgery
JF - Minerva Surgery
ER -