TY - JOUR
T1 - Baclofen in the treatment of persistent hiccup: a case series.
AU - Mirijello, Antonio
AU - Addolorato, Giovanni
AU - D'Angelo, Cristina
AU - Ferrulli, Anna
AU - Vassallo, Gabriele Angelo
AU - Antonelli, Mariangela
AU - Leggio, Lorenzo
AU - Landolfi, Raffaele
PY - 2013
Y1 - 2013
N2 - Abstract
BACKGROUND:
Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.
AIM:
To test baclofen administration for the treatment of persistent hiccup.
METHOD:
We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.
RESULTS:
Hiccup stopped in all patients after a single administration of the drug.
CONCLUSIONS:
Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
AB - Abstract
BACKGROUND:
Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.
AIM:
To test baclofen administration for the treatment of persistent hiccup.
METHOD:
We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.
RESULTS:
Hiccup stopped in all patients after a single administration of the drug.
CONCLUSIONS:
Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
KW - baclofen
KW - treatment
KW - baclofen
KW - treatment
UR - http://hdl.handle.net/10807/52842
U2 - 10.1111/ijcp.12184
DO - 10.1111/ijcp.12184
M3 - Article
SP - 918
EP - 921
JO - internal journal of clinical practice
JF - internal journal of clinical practice
ER -