TY - JOUR
T1 - B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage
AU - Dal Bo, M
AU - Del Giudice, I
AU - Bomben, R
AU - Capello, D
AU - Bertoni, Francesco
AU - Forconi, F
AU - Laurenti, Luca
AU - Rossi, Dario
AU - Zucchetto, A
AU - Pozzato, G
AU - Marasca, R
AU - Efremov, Dg
AU - Guarini, A
AU - Del Poeta, G
AU - Foà, R
AU - Gaidano, G
AU - Gattei, V.
PY - 2011
Y1 - 2011
N2 - The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an important predictor of prognosis in chronic lymphocytic leukaemia (CLL) since 1999. More recently, other features of the B-cell receptor, such as stereotypy, have been identified as capable of refining the prognostic potential of IGHV status in the clinical assessment of CLL patients. In this context, different genes belonging to the IGHV3 subgroup, the most frequently used subgroup in CLL, have been shown to denote disease subsets that either display a bad prognosis (i.e. IGHV3-21, IGHV3-23) or are associated with particularly good clinical outcomes, including a highly stable/indolent clinical course, even prone to spontaneous regression (i.e. IGHV3-72, IGHV3-30). The present review focuses on the molecular and biological features of CLL-expressing specific genes belonging to the IGHV3 subgroup that are known to mark disease subsets with completely different clinical courses, and may be possibly related to CLL pathogenesis via antigen and/or superantigen involvement.
AB - The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an important predictor of prognosis in chronic lymphocytic leukaemia (CLL) since 1999. More recently, other features of the B-cell receptor, such as stereotypy, have been identified as capable of refining the prognostic potential of IGHV status in the clinical assessment of CLL patients. In this context, different genes belonging to the IGHV3 subgroup, the most frequently used subgroup in CLL, have been shown to denote disease subsets that either display a bad prognosis (i.e. IGHV3-21, IGHV3-23) or are associated with particularly good clinical outcomes, including a highly stable/indolent clinical course, even prone to spontaneous regression (i.e. IGHV3-72, IGHV3-30). The present review focuses on the molecular and biological features of CLL-expressing specific genes belonging to the IGHV3 subgroup that are known to mark disease subsets with completely different clinical courses, and may be possibly related to CLL pathogenesis via antigen and/or superantigen involvement.
KW - Gene Expression
KW - Genes, Immunoglobulin Heavy Chain
KW - Humans
KW - Immunoglobulin Variable Region
KW - Leukemia, Lymphocytic, Chronic, B-Cell
KW - Prognosis
KW - Receptors, Antigen, B-Cell
KW - Gene Expression
KW - Genes, Immunoglobulin Heavy Chain
KW - Humans
KW - Immunoglobulin Variable Region
KW - Leukemia, Lymphocytic, Chronic, B-Cell
KW - Prognosis
KW - Receptors, Antigen, B-Cell
UR - http://hdl.handle.net/10807/4963
U2 - 10.1111/j.1365-2141.2010.08440.x
DO - 10.1111/j.1365-2141.2010.08440.x
M3 - Article
SN - 1365-2141
VL - 153
SP - 3
EP - 14
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -