B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

Luca Laurenti, M Dal Bo, I Del Giudice, R Bomben, D Capello, Francesco Bertoni, F Forconi, Dario Rossi, A Zucchetto, G Pozzato, R Marasca, Dg Efremov, A Guarini, G Del Poeta, R Foà, G Gaidano, V. Gattei

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an important predictor of prognosis in chronic lymphocytic leukaemia (CLL) since 1999. More recently, other features of the B-cell receptor, such as stereotypy, have been identified as capable of refining the prognostic potential of IGHV status in the clinical assessment of CLL patients. In this context, different genes belonging to the IGHV3 subgroup, the most frequently used subgroup in CLL, have been shown to denote disease subsets that either display a bad prognosis (i.e. IGHV3-21, IGHV3-23) or are associated with particularly good clinical outcomes, including a highly stable/indolent clinical course, even prone to spontaneous regression (i.e. IGHV3-72, IGHV3-30). The present review focuses on the molecular and biological features of CLL-expressing specific genes belonging to the IGHV3 subgroup that are known to mark disease subsets with completely different clinical courses, and may be possibly related to CLL pathogenesis via antigen and/or superantigen involvement.
Lingua originaleEnglish
pagine (da-a)3-14
Numero di pagine12
RivistaBritish Journal of Haematology
Volume153
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Gene Expression
  • Genes, Immunoglobulin Heavy Chain
  • Humans
  • Immunoglobulin Variable Region
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Prognosis
  • Receptors, Antigen, B-Cell

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