TY - JOUR
T1 - B cell activating factor (BAFF) and BAFF receptors: fakes and facts
AU - Ferraccioli, Gianfranco
AU - Gremese, Elisa
PY - 2017
Y1 - 2017
N2 - Analysis of B cell activating factor (BAFF) receptors before and after B cell depletion therapy (BCDT) might offer a clue to the understanding of whether some B cell subsets may represent useful biomarkers of biological and clinical responses. Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change, whereas the most important, BAFF receptor 3 (BR3), appears to be decreased before as well as after BCDT in all B cell subsets but not in plasmablasts, the most important subset, depleted by BCDT.
AB - Analysis of B cell activating factor (BAFF) receptors before and after B cell depletion therapy (BCDT) might offer a clue to the understanding of whether some B cell subsets may represent useful biomarkers of biological and clinical responses. Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change, whereas the most important, BAFF receptor 3 (BR3), appears to be decreased before as well as after BCDT in all B cell subsets but not in plasmablasts, the most important subset, depleted by BCDT.
KW - Animals
KW - Arthritis, Rheumatoid
KW - B cell depletion therapy
KW - B-Cell Activating Factor
KW - B-Cell Activation Factor Receptor
KW - B-Lymphocytes
KW - BAFF
KW - BAFF receptors
KW - BR3
KW - Flow Cytometry
KW - Humans
KW - Immunology
KW - Immunology and Allergy
KW - Lymphocyte Depletion
KW - Transmembrane Activator and CAML Interactor Protein
KW - rheumatoid arthritis
KW - Animals
KW - Arthritis, Rheumatoid
KW - B cell depletion therapy
KW - B-Cell Activating Factor
KW - B-Cell Activation Factor Receptor
KW - B-Lymphocytes
KW - BAFF
KW - BAFF receptors
KW - BR3
KW - Flow Cytometry
KW - Humans
KW - Immunology
KW - Immunology and Allergy
KW - Lymphocyte Depletion
KW - Transmembrane Activator and CAML Interactor Protein
KW - rheumatoid arthritis
UR - http://hdl.handle.net/10807/122671
UR - http://www.blackwellpublishing.com/cei_enhanced
U2 - 10.1111/cei.13039
DO - 10.1111/cei.13039
M3 - Article
SN - 0009-9104
VL - 190
SP - 291
EP - 292
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
ER -