Azole interactions with multidrug therapy in pediatric oncology

Antonio Ruggiero, Roberta Arena, Andrea Battista, Daniela Rizzo, Giorgio Attinà, Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)


Patients with cancer receive multidrug therapy. Antineoplastic agents and supportive care drugs are often administered together, leading to potential drug-drug interactions. These interactions may have significant clinical implications in terms of toxicity or a decrease in the efficacy of the treatment administered. Here, we focus on the role of azoles and their main pharmacokinetic interactions with the principal classes of drugs used in pediatric oncology. The co-administration of azoles and antineoplastic agents, corticosteroids, immunosuppressants, antacids, antiemetics, antiepileptic drugs and analgesics was investigated, and a practical guide on the management of these drugs when administered together is provided.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaEuropean Journal of Clinical Pharmacology
Stato di pubblicazionePubblicato - 2013


  • azole
  • children
  • multidrug therapy


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