TY - JOUR
T1 - Autologous Bone Marrow Stem Cells in Patients With Critical Limb Ischaemia not Eligible for Revascularization: A Single Centre Experience
AU - Modugno, Pietro
AU - Cilla, Savino
AU - Centritto, Enrico Maria
AU - Picone, Veronica
AU - Maiorano, Maurizio
AU - Amatuzio, Mariangela
AU - Petrilli, Maria Pia
AU - Fraticelli, Vincenzo
AU - De Filippo, Carlo Maria
AU - Caradonna, Eugenio
AU - Codispoti, Franco Alberto
AU - Massetti, Massimo
AU - Tshomba, Yamume
PY - 2024
Y1 - 2024
N2 - We evaluated the use of autologus bone marrow stem cells transplantation in patients with critical limb ischaemia (CLI) not eligible for revascularization. Eighty consecutive patients candidate to amputation were enrolled in a single-centre retrospective study. The primary endpoint was defined as the amputation-free rate from stem cells transplantation. Secondary endpoints were the evaluation of transcutaneous oximetry and its predictive potential for probability of amputation and the evaluation of rest pain. Ankle brachial index, transcutaneous oxygen (TcpO2) and radiological imaging were performed at the enrolment and during the follow-up times. All patients were treated with auto transplant of bone marrow stem cells. Two patients died due to acute renal and acute respiratory failures. 19 patients were amputated from the thigh or leg. In total, 59 of 80 patients intended to thigh amputation saved the limb, preserving the plantar support. TcpO2 was found a predictive metric with an AUC equal to.763, and a threshold for a risk of amputation of 10% and 5% at the values ≤22.7 and ≤26.9 mmHg, respectively. Auto transplant of bone marrow stem cells seems to be a safe and an efficient option for CLI not eligible to revascularizzation.
AB - We evaluated the use of autologus bone marrow stem cells transplantation in patients with critical limb ischaemia (CLI) not eligible for revascularization. Eighty consecutive patients candidate to amputation were enrolled in a single-centre retrospective study. The primary endpoint was defined as the amputation-free rate from stem cells transplantation. Secondary endpoints were the evaluation of transcutaneous oximetry and its predictive potential for probability of amputation and the evaluation of rest pain. Ankle brachial index, transcutaneous oxygen (TcpO2) and radiological imaging were performed at the enrolment and during the follow-up times. All patients were treated with auto transplant of bone marrow stem cells. Two patients died due to acute renal and acute respiratory failures. 19 patients were amputated from the thigh or leg. In total, 59 of 80 patients intended to thigh amputation saved the limb, preserving the plantar support. TcpO2 was found a predictive metric with an AUC equal to.763, and a threshold for a risk of amputation of 10% and 5% at the values ≤22.7 and ≤26.9 mmHg, respectively. Auto transplant of bone marrow stem cells seems to be a safe and an efficient option for CLI not eligible to revascularizzation.
KW - critical limb ischaemia
KW - treatment
KW - stem cells
KW - critical limb ischaemia
KW - treatment
KW - stem cells
UR - http://hdl.handle.net/10807/303009
U2 - 10.1177/00033197231190512
DO - 10.1177/00033197231190512
M3 - Article
SN - 0003-3197
VL - 75
SP - 865
EP - 873
JO - Angiology
JF - Angiology
ER -