Autologous Bone Marrow Stem Cells in Patients With Critical Limb Ischaemia not Eligible for Revascularization: A Single Centre Experience

Pietro Modugno, Savino Cilla, Enrico Maria Centritto, Veronica Picone, Maurizio Maiorano, Mariangela Amatuzio, Maria Pia Petrilli, Vincenzo Fraticelli, Carlo Maria De Filippo, Eugenio Caradonna, Franco Alberto Codispoti, Massimo Massetti, Yamume Tshomba

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

We evaluated the use of autologus bone marrow stem cells transplantation in patients with critical limb ischaemia (CLI) not eligible for revascularization. Eighty consecutive patients candidate to amputation were enrolled in a single-centre retrospective study. The primary endpoint was defined as the amputation-free rate from stem cells transplantation. Secondary endpoints were the evaluation of transcutaneous oximetry and its predictive potential for probability of amputation and the evaluation of rest pain. Ankle brachial index, transcutaneous oxygen (TcpO2) and radiological imaging were performed at the enrolment and during the follow-up times. All patients were treated with auto transplant of bone marrow stem cells. Two patients died due to acute renal and acute respiratory failures. 19 patients were amputated from the thigh or leg. In total, 59 of 80 patients intended to thigh amputation saved the limb, preserving the plantar support. TcpO2 was found a predictive metric with an AUC equal to.763, and a threshold for a risk of amputation of 10% and 5% at the values ≤22.7 and ≤26.9 mmHg, respectively. Auto transplant of bone marrow stem cells seems to be a safe and an efficient option for CLI not eligible to revascularizzation.
Lingua originaleEnglish
pagine (da-a)865-873
Numero di pagine9
RivistaAngiology
Volume75
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • critical limb ischaemia
  • treatment
  • stem cells

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