Autoinflammatory diseases: a possible cause of thrombosis?

Micaela La Regina, Raffaele Manna, Francesco Orlandini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then. Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated. Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations.
Lingua originaleEnglish
pagine (da-a)13-19
Numero di pagine7
RivistaThrombosis Journal
Volume13
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Arterial thrombosis
  • Autoinflammatory diseases
  • Criopyrinopathies
  • Familial mediterranean fever
  • Myocardial infarction
  • Periodic fevers
  • Pyrinopathies
  • Stroke
  • Venous thromboembolism
  • Venous thrombosis

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