Racemic propranolol attenuates cardiac hypertrophy secondary to abdominal aortic banding-induced pressure overload by a mechanism independent of its effect on cardiac work load. This was only observed, however, using doses of propranolol that were much higher than those needed to induce beta-adrenoceptor blockade. Thus, the question remains as to whether the antihypertrophic effect of propranolol depends on its ability to antagonize cardiac beta-adrenoceptor-mediated action (positive chronotropic effect, trophic effect) or on beta-adrenoceptor-independent action.
|Numero di pagine||7|
|Rivista||Journal of Hypertension|
|Stato di pubblicazione||Pubblicato - 2002|
- Adrenergic beta-Antagonists
- Aorta, Abdominal
- Hypertrophy, Left Ventricular
- Rats, Inbred WKY