Abstract
Racemic propranolol attenuates cardiac hypertrophy secondary to abdominal aortic banding-induced pressure overload by a mechanism independent of its effect on cardiac work load. This was only observed, however, using doses of propranolol that were much higher than those needed to induce beta-adrenoceptor blockade. Thus, the question remains as to whether the antihypertrophic effect of propranolol depends on its ability to antagonize cardiac beta-adrenoceptor-mediated action (positive chronotropic effect, trophic effect) or on beta-adrenoceptor-independent action.
Lingua originale | English |
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pagine (da-a) | 763-769 |
Numero di pagine | 7 |
Rivista | Journal of Hypertension |
Volume | 20 |
Stato di pubblicazione | Pubblicato - 2002 |
Keywords
- Adrenergic beta-Antagonists
- Animals
- Aorta, Abdominal
- Disopyramide
- Hypertrophy, Left Ventricular
- Male
- Propranolol
- Rats
- Rats, Inbred WKY
- Stereoisomerism
- Timolol