TY - JOUR
T1 - Attempt to improve transcutateous bilirubinometry: a double blinded study Medick BiliMed versus Respironic BiliCheck
AU - De Luca, Daniele
AU - Zecca, Enrico
AU - Corsello, M.
AU - Tiberi, E.
AU - Semeraro, C.
AU - Romagnoli, Costantino
PY - 2007
Y1 - 2007
N2 - OBJECTIVES: To compare the accuracy of a new transcutaneous bilirubinometer, BiliMed (Medick SA, Paris, France) with BiliCheck (Respironics, Marietta, GA, USA), a widely available instrument, and with total serum bilirubin measurement.
DESIGN: A prospective double-blind study comparing the two devices was carried out. 686 healthy newborns needing measurement of their bilirubin were enrolled over a 4-month period. Serum and transcutaneous bilirubin measurements were taken with both devices within 15 minutes. The order of use of the instruments was randomised.
SETTING: Well-baby nursery ward in a university hospital, tertiary referral centre.
RESULTS: The linear regression analysis showed a better correlation between BiliCheck and serum bilirubin (r = 0.75) than between BiliMed and serum bilirubin (r = 0.45). BiliCheck variability (+/-2 SD of the mean bias from serum bilirubin) was within -87.2 to 63.3 micromol/l, while BiliMed variability was within -97.5 to 121.4 micromol/l. The receiver operating characteristic analysis (for serum bilirubin levels >205.2 micromol/l or >239.4 micromol/l) showed significantly higher areas under the curve for BiliCheck than those for BiliMed (p<0.001).
CONCLUSIONS: Despite the potential practical advantages of BiliMed, its reduced diagnostic accuracy in comparison with BiliCheck does not justify its use in clinical practice.
AB - OBJECTIVES: To compare the accuracy of a new transcutaneous bilirubinometer, BiliMed (Medick SA, Paris, France) with BiliCheck (Respironics, Marietta, GA, USA), a widely available instrument, and with total serum bilirubin measurement.
DESIGN: A prospective double-blind study comparing the two devices was carried out. 686 healthy newborns needing measurement of their bilirubin were enrolled over a 4-month period. Serum and transcutaneous bilirubin measurements were taken with both devices within 15 minutes. The order of use of the instruments was randomised.
SETTING: Well-baby nursery ward in a university hospital, tertiary referral centre.
RESULTS: The linear regression analysis showed a better correlation between BiliCheck and serum bilirubin (r = 0.75) than between BiliMed and serum bilirubin (r = 0.45). BiliCheck variability (+/-2 SD of the mean bias from serum bilirubin) was within -87.2 to 63.3 micromol/l, while BiliMed variability was within -97.5 to 121.4 micromol/l. The receiver operating characteristic analysis (for serum bilirubin levels >205.2 micromol/l or >239.4 micromol/l) showed significantly higher areas under the curve for BiliCheck than those for BiliMed (p<0.001).
CONCLUSIONS: Despite the potential practical advantages of BiliMed, its reduced diagnostic accuracy in comparison with BiliCheck does not justify its use in clinical practice.
KW - Medick BiliMed
KW - Respironics BiliCheck
KW - transcutaneous bilirubinometry
KW - Medick BiliMed
KW - Respironics BiliCheck
KW - transcutaneous bilirubinometry
UR - http://hdl.handle.net/10807/22787
M3 - Article
SN - 1359-2998
SP - 135
EP - 139
JO - ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION
JF - ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION
ER -